DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4b1 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	128/548 - (23%)
Similarity:	228/548 - (41%)	Gaps:	112/548 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 ASVVILMVTVLKLLSLL----------FRRQKLARALDSFPGPPKHWLFGHALEIQKTGGLDKV- 70
            |...||....:.||::|          |:|:.:     .|..|  |.:.|:..|:|||..:.::
  Fly     2 ALTYILFQVAVALLAILTYYIHRKLTYFKRRGI-----PFVAP--HLIRGNMEELQKTKNIHEIF 59

Mouse    71 -----------VTWTEQFPYAHPLWLGQFIVFLNIYE----PDYA----KAVY--SRGDPKAAYV 114
                       ..:...|.:..|   ..|::.|.:.:    .|::    |.::  .:.||.:|::
  Fly    60 QDHYNKFRESKAPFVGFFFFQSP---AAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHL 121

Mouse   115 YDFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLK----PYVAIFAESTRVMLDKWEKKASEN 175
            ::            |:|.:|...|..|:..|....:|    ..|::..|...||    .:|..:|
  Fly   122 FN------------LDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVM----HEKVPKN 170

Mouse   176 KSFDIFCDVGHMALDTLMKCTFGKGDSGLSHSDNSY-YLAVSDL------TLLMQQRIDSFQYHN 233
            ...:|...|....:|.:..|.||...:.|......: |.....|      |||           |
  Fly   171 SVLEIRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLL-----------N 224

Mouse   234 DFIYWLTPHGRR--FLRACQIAHDHTDHVIRQRKAALQDEKEQKKLQERRHL---DFLDILLGAR 293
            .|:.......|:  .:|......:....::.:..|          ::|:.|:   ||:|:|:..:
  Fly   225 GFMRSYPKLARKLGMVRTAPHIQEFYSRIVTETVA----------VREKEHIKRNDFMDMLIELK 279

Mouse   294 DESGIKLSDAD---------LRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREIL 349
            ::..:.|.:.|         :.|:...|...|.:|::|.:.:.||.:|..|..|.:.|.||.|::
  Fly   280 NQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVI 344

Mouse   350 GDRD-SFQWDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRS---LPAGSLISLHIY 410
            ...| :|.::....:.||...:.|..|||..||.:.|..:|... |.|..   :.||..:.:...
  Fly   345 EQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYV-VPGHPNFVIEAGQSVIIPSS 408

Mouse   411 ALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFE 475
            |:|.:.:::|:|..|.|.|||||...||...|::||..|||||||.:|...:.::..||.:..|:
  Fly   409 AIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK 473

Mouse   476 F---SPDPSKIPIKVPQLILRSKNGIHL 500
            |   |..|:.:.......:|..|:||:|
  Fly   474 FSTCSKTPNPLVYDPKSFVLGVKDGIYL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	118/506 (23%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	119/506 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900