DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4b1 and Cyp4p2

DIOPT Version :9

Sequence 1:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus
Sequence 2:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	158/536 - (29%)
Similarity:	254/536 - (47%)	Gaps:	75/536 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 LWASVVILMVT--VLK------LLSLLFRR--QKLARALDSFP----------------GPPKHW 53
            ||.||.||:|.  :.|      :|:...||  .|..:.|||..                |.....
  Fly     6 LWISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDTDQ 70

Mouse    54 LFGHALEIQKTGGLDKVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKAVYSRGDPK---AAYVY 115
            :|.|..::.|..| |..:.::          :|    |.|....|...|......|.   ...:|
  Fly    71 VFTHLRQLAKNSG-DSYLQYS----------MG----FSNFNVIDAHNAANILNHPNLITKGVIY 120

Mouse   116 DFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIF-AESTRVMLDKWEKKASENKSFD 179
            :|...::..|:|.....||...|.:||..||.|:|..:..|| |||.:.:    .:...:|:...
  Fly   121 NFLHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFV----SQFQGQNEVVV 181

Mouse   180 IFCD-VGHMALDTLMKCTFG-KGDSGLSHSDN---SYYLAVSDLTLLMQQRIDSFQYHNDFIYWL 239
            ...| :....|:::.:...| |.|......|.   ::::....||    :||.:..|.:|.:|.:
  Fly   182 SLKDRISRFTLNSICETAMGIKLDEMAEKGDRYRANFHIIDEGLT----RRIVNPLYWDDCVYNM 242

Mouse   240 TPHGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKKLQE----------RRHLDFLDILLGARD 294
            .. |.::..|.::.|:.:..:|.:|:..|::|.|.::..:          ::....||.|:.| :
  Fly   243 FT-GHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICA-E 305

Mouse   295 ESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVRE-ILGDRDSFQWD 358
            :.|: :.|..:..||||.|.||:|||:.|:.:.|..|:||...|:.|.:|::| ||.|..:....
  Fly   306 KDGL-IDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLS 369

Mouse   359 DLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPE 423
            .|:::.||...:||..||||.:|.:.||..:.....:|..||..|.|::|::.:|||...|..||
  Fly   370 QLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYWESPE 434

Mouse   424 VFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSP--DPSKIPIK 486
            .|.|.||.|:|...|||:|::|||||.||||||::||.|||.:..:.|..|:..|  ||..|..:
  Fly   435 EFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQ 499

Mouse   487 VPQLILRSKNGIHLYL 502
            | .:.||.||.|.:.|
  Fly   500 V-GITLRFKNKIKVKL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	142/490 (29%)
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	142/477 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850