DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4b1 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	165/543 - (30%)
Similarity:	267/543 - (49%)	Gaps:	76/543 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 LGLWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALEIQKTGG--LDKVVTWTE 75
            |.::.::.:|:|..|:|.:  |||:   |.|:.|.||....|.|:|.::.|...  ||.|.:|..
  Fly     5 LYIFLALPLLLVAYLELST--FRRR---RVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWH 64

Mouse    76 QFPYAH-PLWLGQFIVFLNIYEPDYAKAVYS------RGDPKAAYVYDFFLQWIGKGLLVLEGPK 133
            |:...: ..|:|.:...| :....|.:.:.|      :.|     :|.....|:|.|||...|.|
  Fly    65 QYGKDNFVFWIGTYSNVL-VTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTGSK 123

Mouse   134 WFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFG 198
            |.:|||::||.||:::|:.:..:..|::...:...:..|:.:..||......::.||.:.....|
  Fly   124 WHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMG 188

Mouse   199 KGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHTDHVIRQ 263
            ...:.:.:..:|...|..|:...:..|.......|:.:|.|.|....:.|..:...|.|:.:|.:
  Fly   189 VSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAK 253

Mouse   264 RKAALQ---------DEKEQKKLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGHDT 319
            |..|.:         ||..:||:.      |||.||.:..: |..|:..:|..||.|||||||||
  Fly   254 RIEAHKSGAVSTNAGDEFTRKKMA------FLDTLLSSTID-GRPLNSKELYEEVSTFMFEGHDT 311

Mouse   320 TTSGISWFLYCMALYPMHQQRCREEVREILGD----RD-SFQWDDLAQMTYLTMCMKECFRLYPP 379
            ||||:|:.:|.::.:...|::..:|.||::|:    || :||  :::||.||.:.:||..|:||.
  Fly   312 TTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQ--EISQMKYLDLFIKEAQRVYPS 374

Mouse   380 VPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFM 444
            ||.:.|...|... :||..:|.|:.::|.:..|..|..|:.||..|.|.||..|.   ..||.::
  Fly   375 VPFIGRFTEKDYV-IDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEK---PGPFEYV 435

Mouse   445 PFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSP--------------------------DPSK- 482
            ||||||||||||:||:.|:|.|.:..:..||..|                          ||.:
  Fly   436 PFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRH 500

Mouse   483 --IPIKVPQLILRSKNGIHLYLK 503
              .||....|.|:|:||:::.||
  Fly   501 KYDPILSAVLTLKSENGLYIRLK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	152/504 (30%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	142/452 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650