DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4b1 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	152/558 - (27%)
Similarity:	256/558 - (45%)	Gaps:	65/558 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MALSFLSPSLSRLGLWASVVIL----MVTVL--KLLSLLF-----RRQKLARALDSFPGPPKHWL 54
            ||:..:..:|.:....:|..:|    |:|.|  .|:::..     |..:..|.:.:.|.||:..:
  Fly     1 MAVEVVQETLQQAASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPI 65

Mouse    55 FGHA--------LEIQKTGGLDKVVTWTEQFPYAHPLWLGQ-FIVFLNIYEPDYAKAVYS-RGDP 109
            .|.|        .||...|     :.:..::......|||. .:|||.  .|...:.:.| ....
  Fly    66 LGQAHVAAGLSNAEILAVG-----LGYLNKYGETMKAWLGNVLLVFLT--NPSDIELILSGHQHL 123

Mouse   110 KAAYVYDFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASE 174
            ..|..|.:|..|.|.|||:..|..|..|||::.|.||..:||.:|..|.:.::.::.:...:|
  Fly   124 TKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEA-- 186

Mouse   175 NKSFDIFCDVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWL 239
            .||||:...:....:|.|:....|.......:....|..||.|:..::.:|.....|..|.||..
  Fly   187 GKSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKF 251

Mouse   240 TPHGRRFLRACQIAHDHTDHVIRQRKAALQDEK-----------------------------EQK 275
            |....:..|...|....|..|::.||...|:|.                             ::.
  Fly   252 TKLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDEN 316

Mouse   276 KLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQR 340
            .:..:|.|..||.::.......|:.::.|:..||:|.||||||||::|.|:.|..|.::...|.:
  Fly   317 DVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAK 381

Mouse   341 CREEVREILGD---RDSFQWDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDG-RSLPA 401
            ...|.:.|.||   ||. .:.|..:|.||...:.|..|||||||.:.|:|...:....| .::|.
  Fly   382 VFAEQKAIFGDNMLRDC-TFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPK 445

Mouse   402 GSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVV 466
            |:.:.:..|.:||...::|:|..|||..|.||.|..||.::|:|||||||:|:|:::||.::||:
  Fly   446 GTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVL 510

Mouse   467 TALCLLRFEFSPDPSKIPIKV-PQLILRSKNGIHLYLK 503
            .:..:..:......::...|: ..:||:.:||.::.|:
  Fly   511 LSTIVRNYIVHSTDTEADFKLQADIILKLENGFNVSLE 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	140/496 (28%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	135/469 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920