DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a14 and Cyp4aa1

DIOPT Version :9

Sequence 1:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus
Sequence 2:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	142/521 - (27%)
Similarity:	239/521 - (45%)	Gaps:	80/521 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    24 LLSLFLVLFKA-VQFYLRRQWLLKTLQHFPCMPSHWLWGHHL--KDKELQQ-------------I 72
            ::||.:..|.| :..|||...|...|...|.:|   ..|:.:  .||:|.:             :
  Fly    23 VISLSIYTFYATLNTYLRSVLLSLRLTGPPSLP---FLGNCMLVTDKDLMRRCAGKAFDLYGSLV 84

Mouse    73 LIWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVLGRSDPKASGIYQFFAPWIGYGLLLLNGKKWF 137
            .|||..||...:  |...:::|:|....:...|.         .|:....::|.||:..:|.||.
  Fly    85 RIWVLLFPFFAV--LEPEDLQVILSSKKHTNKVF---------FYRLMHNFLGDGLITSSGSKWS 138

Mouse   138 QHRRMLTPAFHYDILKPYVKIMADSVNIMLDKWEKLDGQDHPLEI------FHCVSLMTLDTVMK 196
            .|||::.||||:::|:.::....|:...:   :|.||.:....||      .:||..:..:.|:.
  Fly   139 NHRRLIQPAFHHNLLEKFIDTFVDASQSL---YENLDAEAVGTEINIAKYVNNCVLDILNEAVLG 200

Mouse   197 CAFSYQG-SVQLDENSKL----------YTKAVEDLNNLTFFRLRNAFYKYNIIYN--MSSDGRL 248
            .....:| .|.:.|:|..          :|:.         :.|.:..|.:..:.|  ::...||
  Fly   201 VPIKKRGQDVAMMEDSPFRQGKIMMPARFTQP---------WLLLDGIYHWTKMANDELNQKKRL 256

Mouse   249 SHHACQIAHEHTDGVIKMRKSQLQNEEELQKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVD 313
                    ::.|..:|: |:.|:||.......||......::|     .|.....::||:..|..
  Fly   257 --------NDFTRKMIQ-RRRQIQNNNNGNSERKCLLDHMIEI-----SESNRDFTEEDIVNEAC 307

Mouse   314 TFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDGT-SVTWDHLGQMPYTTMCIKEAL 377
            |||..|.|:..:.:::..:.|..:||.|.||..|:.:|..|.. :.|...|.:|.|..|||||||
  Fly   308 TFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEAL 372

Mouse   378 RLYPPVISVSRELSSPVTFPDGRSIPKGITATISIYGLHHNPRFWPNPKVFDPSRFAPDSS--HH 440
            ||||.|..::|:|...|.... .::|.|....|..|..|.....:|:|:.|.|.||:|::|  .|
  Fly   373 RLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRH 436

Mouse   441 SHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIA-RLVLKSKNGIHLCLK 504
            .:|:||||.|.|.|||.:||:.|:|..|:..|..::|||...:..:... |:.|::..|:.:.||
  Fly   437 PYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLK 501

Mouse   505 K 505
            :
  Fly   502 E 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	131/486 (27%)
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	126/465 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750