DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a14 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	132/529 - (24%)
Similarity:	225/529 - (42%)	Gaps:	71/529 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    21 WAFLLSLFLVLFKAVQFYLRRQWLLKTLQHF------PCMPSHWLWGHHLKDKELQQIL--IWVE 77
            ::.||::.:||..    ||..:|  :...|:      ||...|.|.| .|...:..:..  ||::
  Fly     4 YSVLLAIVVVLVG----YLLLKW--RRALHYWQNLDIPCEEPHILMG-SLTGVQTSRSFSAIWMD 61

Mouse    78 ---KF----PSACLQCLSGSNIRVLLYDPDYVKVVLGRSDPKAS--GIYQFFA--PWIGYGLLLL 131
               ||    |.|.........|.||  |....|::|.:...|.:  |.|....  |..|. |.||
  Fly    62 YYNKFRGTGPFAGFYWFQRPGILVL--DISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQ-LFLL 123

Mouse   132 NGKKWFQHRRMLTPAFHYDILK----PYVKIMADSVNIMLDKWEKLDGQDHPL-EIFHCVSLMTL 191
            :|:||...|..|:..|....:|    ..||:..:.:.:.....||     .|: |:...::..|.
  Fly   124 DGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEK-----SPIVEVRDILARFTT 183

Mouse   192 DTVMKCAFSYQGSVQLDENSKLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIA 256
            |.:..|||..:.|...|..::...     :.....|..|:.......|.:..:..|..|  .:|.
  Fly   184 DVIGTCAFGIECSSLKDPEAEFRV-----MGRRAIFEQRHGPIGIAFINSFQNLARRLH--MKIT 241

Mouse   257 HEHTDGVIKMRKSQLQNEEELQKARKKRHL---DFLDILL------FARMEDRNS--LSDEDLRA 310
            .|..:...      |:...|....|:|.::   ||:|.|:      ..:.|...|  |:.|::.|
  Fly   242 LEEAEHFF------LRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAA 300

Mouse   311 EVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGD-GTSVTWDHLGQMPYTTMCIK 374
            :...|...|.:|:::.:.:..|.||.|.:.|.|.|:|.|.::|. ...:|::.:..|.|....|.
  Fly   301 QAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVIS 365

Mouse   375 EALRLYPPVISVSRELSSPVTFPDGRS--IPKGITATISIYGLHHNPRFWPNPKVFDPSRFAPD- 436
            |.||||..:..::||.......|....  |.||:...|....:|.:.:.:.||..|:|..|:|:
  Fly   366 ETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPER 430

Mouse   437 -SSHHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFEL-LPDPTRIPVPIAR--LVLKSKN 497
             ....|..:|||..|.|||||.:|...:.:..:||.:.||:. :.:.|.||:..::  .::.|:.
  Fly   431 VKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSET 495

Mouse   498 GIHLCLKKL 506
            ||.|.::::
  Fly   496 GIFLKVERV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	123/485 (25%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	123/485 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810