DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a14 and Cyp318a1

DIOPT Version :9

Sequence 1:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus
Sequence 2:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	106/500 - (21%)
Similarity:	202/500 - (40%)	Gaps:	123/500 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    69 LQQILIW----VEKFPSACLQCLSGSNI------------RVLLY--DPDYVKVVLGRSDPKASG 115
            :||.::|    :...|::.|:.:|...:            |||||  ||..::.||...:.....
  Fly    39 IQQPVLWLLLCINLHPNSILEKVSQYRVHFQRPLAVLVGTRVLLYIDDPAGMECVLNAPECLDKT 103

Mouse   116 IYQ--FFAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVNIMLDKWE---KLDG 175
            ..|  ||   :..|||...|:||...|:.|.|||.::|:..:..:.....|.|:::::   .|.|
  Fly   104 FLQDGFF---VRRGLLHARGQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHG 165

Mouse   176 QDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLDENSKLYTKAVEDLNNLT-------FFRLRNAF 233
            |                           :|:......|.::||.:::.||       |.:|.:|.
  Fly   166 Q---------------------------AVKFTAAEDLLSRAVLEVSCLTIMGTPTNFTQLDDAH 203

Mouse   234 --YKYNIIYNMSS--------DGRLSHH------------ACQIAHEHTDGVI--KMRKSQLQNE 274
              :.|..:..:|:        ..||.|.            ..::..:...|::  |.|..:|::.
  Fly   204 IAHSYKRLLEISAVRVVKPWLQIRLLHRLLAPELYEESKKCAKLLEDFVGGIVRTKHRNWRLRDA 268

Mouse   275 -------EELQKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFY 332
                   |:.....::|  .|::.:.  ::.....::.|::..|..:.:....:|.::.|.....
  Fly   269 VGGEKSGEDASNGWQRR--IFIEQIF--QLAANGEMTLEEIMDEAQSMVLVSFETVSNSIMLALL 329

Mouse   333 ALATHP-EHQQRCREEVQSILGDGTSVTWDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTF 396
            .|||:. :.|:|...|:::::.|...|..:.|.|:.|....:.|:|||...|....|.:|.....
  Fly   330 CLATNKGDCQRRLLAEIRALVPDVGQVGLEQLQQLRYLDAFVSESLRLLATVPMNLRHVSRDFRL 394

Mouse   397 PDGRS----IPKGITATISIYGLHHNPRFW-PNPKVFDPSRFAP-----------DSS------- 438
            . ||.    :|:.....:..:.:..:.|:| .|.:.|||.||..           ||.
  Fly   395 A-GRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQ 458

Mouse   439 ---HHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPD 480
               .||:::||||.|.|:|||:::.:..:||.:...:..|:...|
  Fly   459 RDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQSD 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	105/499 (21%)
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	103/495 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910