DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a14 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	148/540 - (27%)
Similarity:	249/540 - (46%)	Gaps:	60/540 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 ISGFFQWAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGH-H----LKDKELQQI-L 73
            :.||......|...||.....:::.|.....:.:.:.|..|...:.|. |    |.:.|:..: |
  Fly    21 VLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGL 85

Mouse    74 IWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVL-GRSDPKASGIYQFFAPWIGYGLLLLNGKKWF 137
            .::.|: ...::...|:.:.|.|.:|..::::| |......:..|::|.||.|.|||:.||..|.
  Fly    86 GYLNKY-GETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWR 149

Mouse   138 QHRRMLTPAFHYDILKPYVKIMADS-----VNIMLDKWEKLDGQDHPLEIFHCVSLMTLDTVMKC 197
            .||:|:.|.||..|||.:|....|.     ..:.|:..:..|..|:       :|..|:|.::..
  Fly   150 HHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAGKSFDVHDY-------MSQTTVDILLST 207

Mouse   198 AFSYQGSVQLDENSKL--YTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAHEHT 260
            |   .|..:|.|.:|.  |.:||.|:.::...|.....|:.:.||..:...........|....|
  Fly   208 A---MGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMT 269

Mouse   261 DGVIKMRKSQLQNE-----EELQ-------KARK-----------------KRHLDFLDILLFAR 296
            ..|:|.||...|.|     ||:.       .::|                 ||.|..||.::...
  Fly   270 SKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMA 334

Mouse   297 MEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDG--TSVT 359
            .......:::|:..||:|.||||||||::|.|:....:..|.:.|.:...|.::|.||.  ...|
  Fly   335 KNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCT 399

Mouse   360 WDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDG-RSIPKGITATISIYGLHHNPRFWP 423
            :....:|.|....|.|.|||||||..::|.|...:....| .::|||.|..:..|.:|..|..:|
  Fly   400 FADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYP 464

Mouse   424 NPKVFDPSRFAPD--SSHHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPV 486
            ||..|||..|.|:  ::.|.::::|||.|.|:|:|:::||.:|||.::..:..:.:....|....
  Fly   465 NPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADF 529

Mouse   487 PI-ARLVLKSKNGIHLCLKK 505
            .: |.::||.:||.::.|:|
  Fly   530 KLQADIILKLENGFNVSLEK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	140/497 (28%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	134/470 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920