Protein Alignment Cyp4a12b and Cyp4p1

DIOPT Version :10

• Sequence 1: NP_758510.2
• Gene: Cyp4a12b / 13118
• MGIID: 3611747
• Length: 508
• Species: Mus musculus
• Sequence 2: NP_524828.1
• Gene: Cyp4p1 / 45524
• FlyBaseID: FBgn0015037
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 152/530 - (28%)
• Similarity: 254/530 - (47%)
• Gaps: 70/530 - (13%)

Mouse    24 VLSLLLLLFKTAQLYLHRQWLLSSTQQF----------------------PSPPSHWLFGHKI-L 65
            ::.|.|:|..:|.||    ||..:.:.:                      |......:||:.: |
  Fly     1 MIILWLILALSALLY----WLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDL 61

Mouse    66 KDQDLQDILT----RIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKAHG-SYRFLAPWI 125
            ..:|...:..    |.|...::..::::| |....:.|.|..:.:|...:....| .|.||.|::
  Fly    62 YGRDHAGVFNYSRERAKEMGTSYIEYVFG-KAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFL 125

Mouse   126 GRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDS-TLEIFQHITL 189
            ..|||...|:.|...|:||||.||::||..:.||........|.::|   |||. |:.:...|..
  Fly   126 RTGLLTSTGKKWHARRKMLTPTFHFNILNQFQEIFKTESQKFLLQFE---GQDEVTITLHDVIPR 187

Mouse   190 MTLDTIMKCAFSHEGSVQLDR------KYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGC 248
            .||::|.:.|.    .|:||.      :|:.....:|:   .|..|:.|.....|.::.:.:...
  Fly   188 FTLNSICETAM----GVKLDEMAEKGDRYRENFSQIEE---CFIRRLSNPLLWGDKLFEMFAAKD 245

Mouse   249 LANSACQLAHDHTDQVIKSRRSQLQDEEELEK---------LKKKRRLDFLDILLFARMENGKSL 304
            .| ||..:.|..:.::|..||..|:|  ||:|         ...|:|...||.|::|  |....:
  Fly   246 FA-SALDVVHRFSSEIIAKRRDLLKD--ELDKSSSTADDDGFVSKKRFAMLDTLIYA--EKDGLI 305

Mouse   305 SDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGAS-ITWNDLDKMP 368
            ....:..||||.||||:|||:.|:.:....::.||:.|:.|.:|||..:.|..| :....|:|:.
  Fly   306 DHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSNLDVGQLNKLK 370

Mouse   369 YTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSR 433
            |....:||..|::|.||.:.||........:|..||||..:.:..:.:|.|...|.:||.|.|.|
  Fly   371 YLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHRNAKYWDSPEEFRPER 435

Mouse   434 FAPGS--SRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP--DPTRVPIPIPRIVL 494
            |.|.:  .||:::::|||.|.||||||::||.|:|..:.:.|.:|::|.  ||.:: :....|.|
  Fly   436 FLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAIDPQKI-VFHTGITL 499

Mouse   495 KSKNGIHLHL 504
            ::::.|.:.|
  Fly   500 RTQDKIRVKL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	138/458 (30%)
Cyp4p1	NP_524828.1	CYP4	87..507	CDD:410721	136/436 (31%)