DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a12b and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	156/553 - (28%)
Similarity:	263/553 - (47%)	Gaps:	94/553 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 YLQVASVLSLLLLLFKTAQLYLHRQW-------------LLSSTQQFPSPPSHWL---FG--HKI 64
            ::.:.:.|:|.|.|....:|.|.|:.             |:.:..|..:.|:..|   ||  |:.
  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEY 66

Mouse    65 LKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLIL------GRSDPKAHGSYRFLAP 123
            .||           ||    ..|: |....|.|.:|.||:.||      .:||     .|....|
  Fly    67 GKD-----------NF----RYWI-GYYSNIMVTNPKYMEFILSSQTLISKSD-----VYDLTHP 110

Mouse   124 WIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHIT 188
            |:|.|||...|..|.:||:|:|||||::||:.:.|:|.::....:|:.:::....:..:..:...
  Fly   111 WLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAH 175

Mouse   189 LMTLDTIMKCAFSHEGSVQ-LDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANS 252
            .:|||.|  |..:...|:. ::.:..|.:||.:|:.....:|..:.:.:|..::..:......:.
  Fly   176 YLTLDVI--CDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSK 238

Mouse   253 ACQLAHDHTDQV----IKSRRSQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEV 313
            ..:...|.|:::    |:.|:|.|:...:.::..:| ::.|||.||.:::: |:.|:.::|..||
  Fly   239 TLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRK-KMAFLDTLLSSKVD-GRPLTSQELYEEV 301

Mouse   314 DTFMFEGHDTTASGISWIFYALATNPEHQQRCRKE---IQSLLGDGASITWNDLDKMPYTTMCIK 375
            .||||||||||.||:.:..|.|:.:|:.|::...|   :....|.|...|:.::..|.:..:.||
  Fly   302 STFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIK 366

Mouse   376 EALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRF---APG 437
            ||.|:||.||.:.|........ ||..:|||..:.|....|.:|..|:.:|..|.|.||   .||
  Fly   367 EAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG 430

Mouse   438 SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP------------------DPTR 484
                ...::|||.|.|||||::||:.|:|..|:..:..||:||                  .|..
  Fly   431 ----PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAE 491

Mouse   485 V-----------PIPIPRIVLKSKNGIHLHLKK 506
            .           ||....:.|||:||:||.:|:
  Fly   492 KKSRDAHNHKYDPILSASMTLKSENGLHLRMKQ 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	138/478 (29%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	136/464 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845029
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650