DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a12b and Cyp316a1

DIOPT Version :9

Sequence 1:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus
Sequence 2:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	117/477 - (24%)
Similarity:	205/477 - (42%)	Gaps:	54/477 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    55 PSHW-LFG--HKIL------KDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRS 110
            |..| |.|  ||:|      ..|...:.||:...| |.|  |:: .::.|.:.|.:..:.:| .:
  Fly    34 PFTWPLMGAMHKLLFLTPINFFQRSTEYLTKYGTF-SRC--WVF-HRLFIPLADLELSRQLL-EN 93

Mouse   111 DPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIV 175
            |......|..:..|:..|:|:...:.|.:...:::..|....|:...::.......:|.|..:..
  Fly    94 DTHLETGYELMKDWLVGGVLMCQSEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQA 158

Mouse   176 GQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDII 240
            .| ...:|:..::.:.||.::......:.|       :.|.:.::||:.::..|..::...|...
  Fly   159 DQ-KVFDIWYTVSPIVLDLMVMTTCGAKPS-------EEYSKNLKDLSEIYRKRFLSLQSANRFN 215

Mouse   241 YRVSSNGC--LANSACQLAHDHTDQVIKSRRSQLQ-------DEEELEKLKKKRRLDFLDILLFA 296
            |.:||...  ..|...:..:|..:.::...:||.|       |..:|..:..|.....|:|||.:
  Fly   216 YWLSSPFMRKRQNRLIKRLNDEHNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHKSLLEILLES 280

Mouse   297 RMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGASITW 361
            :   ...|:.:::..|::|..:.|:...:..:.:....:|.||..||:|..|:.  |.......|
  Fly   281 K---DPQLTGEEICGELNTCNYLGYQLCSPALCFCLVTIARNPSVQQKCLDELN--LAQIKDQGW 340

Mouse   362 NDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRS------LPKGIHVMLSFYGLHHNP 420
             ||:|:.|....:.|.:|:|||...|.|:|..  .||...|      ||.|..:.::.|.|..|.
  Fly   341 -DLEKLNYLDAVLHETMRLYPPQVIVGRQLKK--DFPYTHSIVGDAELPCGSEIYINLYELQRNE 402

Mouse   421 TVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP--DPT 483
            ..:|....||..||.....    ..|.:|.|.|.|..::|:|..||..:|..|..||:||  |..
  Fly   403 VRYPKANHFDAQRFLDSPP----ELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEV 463

Mouse   484 RVPIPIPRIVLKSKNGIHLHLK 505
            |:.:   |:||.|.||..|.||
  Fly   464 RLDL---RLVLGSSNGFQLALK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	106/449 (24%)
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	108/456 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820