DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a12b and Cyp4d20

DIOPT Version :9

Sequence 1:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus
Sequence 2:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	147/494 - (29%)
Similarity:	243/494 - (49%)	Gaps:	79/494 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    43 WLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLIL 107
            |:.....::......|:.|..::..:|||                              |.:.||
  Fly    59 WVGEKFDKYGKTFRFWILGESLIYTKDLQ------------------------------YFETIL 93

Mouse   108 GRSDPKAHGS-YRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKW 171
            ..:.....|. |.:|.|::..|||:..|:.|...|::.|.|||:.:|:.|.|||.....||:|..
  Fly    94 SSTTLLEKGQLYEYLRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNL 158

Mouse   172 EQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQ 236
            .::....:.:::.::::|..||.|.:.|...:.:.|.|..: .||:|::.:          ::.|
  Fly   159 RKVADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQNDPDF-PYIKALKSV----------VYIQ 212

Mouse   237 NDIIYRVSS--NGCLANSA----------CQLAHDHTDQVIKSRRS--------------QLQDE 275
            .|.::|.|.  |.....:|          .::.||.||:||..||.              .|.|.
  Fly   213 PDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDA 277

Mouse   276 EELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPE 340
            |    :..|.::..|||||.:.: |.:.|||.|:|.|||||||||.|||:||:|...||:|.:||
  Fly   278 E----IGSKSQMALLDILLQSSI-NNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPE 337

Mouse   341 HQQRCRKEIQSLLGDGAS--ITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSL 403
            .|||..:|:|.:||..||  :|...|..:.|....|||.:|:|||||::.|.....:...| :::
  Fly   338 VQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTI 401

Mouse   404 PKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSR--HSHSFLPFSGGARNCIGKQFAMNELK 466
            |....:.|..|..|.:...:|:|..|.|.||.....:  ::.:::|||.|.:||||::||:.|:|
  Fly   402 PANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMK 466

Mouse   467 VAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLK 505
            |.::..|..:||||....:. |:...:|:|.:||::.|:
  Fly   467 VLISKVLRFYELLPLGEELK-PMLNFILRSASGINVGLR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	142/463 (31%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	142/481 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750