DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a12b and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	138/538 - (25%)
Similarity:	223/538 - (41%)	Gaps:	78/538 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 GSISEYLQVASVL-SLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTR 76
            |..|..|.:..|| ..|||.::.|..|    |   .....|....|.|.|.           ||.
  Fly     2 GVYSVLLAIVVVLVGYLLLKWRRALHY----W---QNLDIPCEEPHILMGS-----------LTG 48

Mouse    77 IKNFPSACPQWL----------------WGSKVRIQVYDPDYMKLILGRSDPK--AHGSYRFLA- 122
            ::...|....|:                |..:..|.|.|....||||.:...|  ..|.|....
  Fly    49 VQTSRSFSAIWMDYYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTED 113

Mouse   123 -PWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQH 186
             |..|: |.|||||.|...|..|:..|....:|.....:....|..::.:.|.:.:...:|:...
  Fly   114 DPLSGQ-LFLLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDI 177

Mouse   187 ITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRV---RNIFHQNDIIYRVSSNGC 248
            :...|.|.|..|||..|.|...|.:.:              .||   |.||.|......::....
  Fly   178 LARFTTDVIGTCAFGIECSSLKDPEAE--------------FRVMGRRAIFEQRHGPIGIAFINS 228

Mouse   249 LANSACQLAHDHTDQVIKSRRSQLQDEEELEKLKKK---RRLDFLDILL------FARMENGKS- 303
            ..|.|.:|....|  :.::....|:...|....::|   ||.||:|.|:      ..:.|:|:|
  Fly   229 FQNLARRLHMKIT--LEEAEHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESV 291

Mouse   304 -LSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGD-GASITWNDLDK 366
             |:.:::.|:...|...|.:|:::.:.:..|.||.:.:.|.|.|||.|.::|. ...||:..:..
  Fly   292 NLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKD 356

Mouse   367 MPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRS--LPKGIHVMLSFYGLHHNPTVWPNPEVF 429
            |.|....|.|.||:|..:|.::||.......|....  :.||:.|::....:|.:..::.||..|
  Fly   357 MVYLDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTF 421

Mouse   430 DPSRFAPG--SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL-LPDPTRVPIPIPR 491
            :|..|:|.  ..|.|..:|||..|.|||||.:|...:.:..:||.:.||:. :.:.|.:||...:
  Fly   422 NPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSK 486

Mouse   492 --IVLKSKNGIHLHLKKL 507
              .::.|:.||.|.::::
  Fly   487 KTFLISSETGIFLKVERV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	122/474 (26%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	126/491 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900