Protein Alignment Cyp4a12b and Cyp9h1

DIOPT Version :10

• Sequence 1: NP_758510.2
• Gene: Cyp4a12b / 13118
• MGIID: 3611747
• Length: 508
• Species: Mus musculus
• Sequence 2: NP_610820.1
• Gene: Cyp9h1 / 36412
• FlyBaseID: FBgn0033775
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 145/553 - (26%)
• Similarity: 242/553 - (43%)
• Gaps: 103/553 - (18%)

Mouse    19 LQVASVLSLLLLLFK--TAQLYLHRQWLLSSTQQFP----SPPSHWLFGHKILKDQDLQDILTRI 77
            :.:|..:.||:||:|  .|:..:..:..:|..:.:|    .|....:.|..:||  .:.::.|:.
  Fly     6 IALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLK--KMIELHTKH 68

Mouse    78 KNFPSACPQWLWG-SKVRIQVY---DPDYMKLILGRSDPKAHGSYRFLAPWIGRGLL------LL 132
            ...|      ::| ..:|..|:   ||:.:||| |..:.....::..:...|...:|      |.
  Fly    69 TGSP------VYGIYALRDAVFFVRDPELIKLI-GIKEFDHFVNHNSMHNNIQESILSKSLISLR 126

Mouse   133 DGQTWFQHRRMLTPAF-------HYDILKPYTEIMADSVHVMLDKWEQI-VGQDST--LEIFQHI 187
            ||: |.:.|.:|||||       .||:::..:|  ...:|:.    ||: :.||::  ||:..:.
  Fly   127 DGR-WKEMRNILTPAFTGSKMRIMYDLIQSCSE--EGVIHIQ----EQLELSQDASIELEMKDYF 184

Mouse   188 TLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANS 252
            |....|.|...||    .:.:               |.|..:....|.....:.|:|:...:.
  Fly   185 TRFANDVIATVAF----GISI---------------NSFRRKDNEFFRIGQAMSRISAWSVVK-- 228

Mouse   253 ACQLAHDHTDQVIKSRRSQLQDEEELEKLK-------------KKRRLDFLDILLFARMENGKSL 304
              .:.:....:::|..|.|:.|.:.::...             |..|.|.:.:|:.|:.:....|
  Fly   229 --AMLYALFPRLMKVLRIQVLDTKNIDYFSSLVTAAMRYRQEHKVVRPDMIHLLMEAKQQRLADL 291

Mouse   305 SDK-------------DLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGD- 355
            |||             ||.|:...|.|.|.:..:|.:.::.:.|..||..|.|..:||.|:..:
  Fly   292 SDKSKDELYYSEFTADDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEEL 356

Mouse   356 -GASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPD--GRSL---PKGIHVMLSFY 414
             |..:|::.|.||.|..|.:.||||.:||..|..||....:...|  |:.|   .||..:.:..:
  Fly   357 KGQPLTYDKLTKMKYLDMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIF 421

Mouse   415 GLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELL 479
            .|||:|..:.:||.|:|.|||.|.:..|..::||..|.|||||.:.|:.|||..|...||.|:||
  Fly   422 SLHHDPENFEDPEFFNPERFADGHALESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLL 486

Mouse   480 PDPTRVPIPIPRIV----LKSKNGIHLHLKKLQ 508
            | ..|....:...:    ||.|||..|..:..|
  Fly   487 P-AKRTSRDLLNDIRGHGLKPKNGFWLKFEARQ 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	130/489 (27%)
Cyp9h1	NP_610820.1	CYP6-like	69..511	CDD:410679	129/479 (27%)