DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a12b and Cyp4ae1

DIOPT Version :9

Sequence 1:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus
Sequence 2:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	150/498 - (30%)
Similarity:	255/498 - (51%)	Gaps:	32/498 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse    24 VLSLLLLLFKTAQLYLHR--QWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTR-IKNFPSACP 85
            |..|:..||:.|...|..  |.::.|..:.|...:.|..  :..:..:|.|.... :|.|..:..
  Fly    11 VTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAWQM--RSFQPDNLHDKFAEYVKRFGRSFM 73

Mouse    86 QWLWGSKVRIQVYDPDYMKLIL-GRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFH 149
            ..:.|..|.:.. :|.::..:| |:...|....|..|..|:|.||||..|:.|...|:::||.||
  Fly    74 GTVLGHVVMVTA-EPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTMRKIITPTFH 137

Mouse   150 YDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRK--Y 212
            :.||:.:.|:......:::::...:...:..:.|:..:.|..||.|.:.|.    .|.:|.:  .
  Fly   138 FSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAM----GVNVDAQGAD 198

Mouse   213 KSYIQAVEDLNNLF---FLRVRNIF-HQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQ 273
            ...:.||:||.|:.   |:|...:| |...:.:........|...|  .|:.|:.:|:.||..|.
  Fly   199 SEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVIC--LHEFTNGIIEQRRRLLA 261

Mouse   274 DEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATN 338
            .|...:|..|...|  ||.||.|.:: |:.|:||.:|.||:||:|||||||.|.:|:..|.|:.:
  Fly   262 REANQDKPTKPHAL--LDTLLRATVD-GQPLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRH 323

Mouse   339 PEHQQRCRKEIQSLLGDG--ASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGR 401
            ...||:..:|::...|..  ..:..:|...:||.:..:||:||:|||:|:|:|.|...:...:|
  Fly   324 EAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKDLVIDEG- 387

Mouse   402 SLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRF----APGSSRHSHSFLPFSGGARNCIGKQFAM 462
            .:|.|.:|::..:.|..:..::.:|.||.|.|.    ||..|  .:|::|||.|.|||||::||:
  Fly   388 YIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLS--PYSYIPFSAGPRNCIGQKFAL 450

Mouse   463 NELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLK 505
            .|:|..|...:..::|||....|. |..:|||:||:|:::.|:
  Fly   451 LEMKTMVTKVIRHYQLLPMGADVE-PSIKIVLRSKSGVNVGLR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	139/446 (31%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	141/466 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740