DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a10 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	163/533 - (30%)
Similarity:	276/533 - (51%)	Gaps:	74/533 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 LSGFLQV-ASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGH---------EKFK--- 66
            :||:..: ..:||.:|:.:  |.:...|..|:|..::.|.|....|.|:         |.|.
  Fly    23 ISGYSPITVFLLGSILIFL--VVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVI 85

Mouse    67 GDQELQEIVSCIENFPSAFPRWFWGSKAYLT-----------VYDPDYMKVILGRSDPKANGA-- 118
            |.|:|                  ||::..:.           :::|:.::.|| .|....|.:
  Fly    86 GMQKL------------------WGTRIGINRVWQGTAPRVLLFEPETVEPIL-NSQKFVNKSHD 131

Mouse   119 YRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQ--DSS 181
            |..|.||:|.|||....:.|...|::||||||:.||..::....:...::..|   ||.:  ..:
  Fly   132 YDYLHPWLGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARK---LAVEVGSEA 193

Mouse   182 IEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYRT-YLQAIGDLNNLFHSRVRNIFHQNDTIYKLS 245
            ..:|.:::|.|||.|.:.|...:  :....|..: |::|:..:.::..||...|:.|:|.|:.|:
  Fly   194 FNLFPYVTLCTLDIVCETAMGRR--IYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDFIFSLT 256

Mouse   246 SNGRLAKQACQLAHDHTDGVIKLRKDQ---LQDEGE---------LEKIKKKRRLDFLDILLFAR 298
            :..:|.:......|..::.||:.||.:   ||:...         .:.:.||:||.|||:|:.|.
  Fly   257 AEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDAS 321

Mouse   299 MENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDG--SSIT 361
            .| |..:|::|:|.|||||||||||||::.:||..:.|..||::|:|..||:.|:.||.  :..|
  Fly   322 KE-GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPAT 385

Mouse   362 WDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPN 426
            ..:|..:.|...|||::|||:|.||.:.|.:...|.. .|:.:|.|.|..:..|.||.||:|:|.
  Fly   386 MKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVFPK 449

Mouse   427 PEVFDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMP 489
            ||.|:|..|.|:  :.||..:::|||.|.|||||::||:.|.|.:::..|.::::.....|..:.
  Fly   450 PEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLT 514

Mouse   490 -LARLVLKSKNGI 501
             |..|:|:.|:|:
  Fly   515 LLGELILRPKDGL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	154/495 (31%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	154/495 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844978
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640