DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a10 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	479	Identity:	120/479 - (25%)
Similarity:	195/479 - (40%)	Gaps:	96/479 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    91 GSKAY----------LTVYDPDYMK---------------VILGRSDPKANGAYRLLAPWIGYGL 130
            |||.:          |.|.|||.:|               |....||...:....|    .|..|
  Fly    66 GSKKFFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNL----FGSSL 126

Mouse   131 LLLNGQPWFQHRRMLTPAF-------HYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHI 188
            ..:....|...|..|:|||       .:.::....|...|.:     |.:....|::.:::..:.
  Fly   127 FSMRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCL-----KQDDSRVQENELDMKDYC 186

Mouse   189 SLMTLDTVMKCAFSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQ 253
            :..|.|.:...||    .:||               |.|..| .|.|:|...  ||::...|...
  Fly   187 TRFTNDVIASTAF----GLQV---------------NSFKDR-ENTFYQMGK--KLTTFTFLQSM 229

Mouse   254 ACQLAHDHTDGVIKLRKDQLQDEGE--------LEKIKKKR-----RLDFLDILLFAR----MEN 301
            ...|.. ...|:.|:.|.:|.|...        |:.:|.::     |.|.:::|:.||    .|.
  Fly   230 KFMLFF-ALKGLNKILKVELFDRKSTQYFVRLVLDAMKYRQEHNIVRPDMINMLMEARGIIQTEK 293

Mouse   302 GDS-----MSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGD--GSS 359
            ..:     .||:|:.|:...|.|.|.:|:|..:.:..:.|..:.|.|||..||||.:..|  |..
  Fly   294 TKASAVREWSDRDIVAQCFVFFFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKE 358

Mouse   360 ITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFP-DGR--SLPKGVQVTLSIYGLHHNP 421
            :|::.:..:.|....:.|.||.:|....:.||.:..:||. ||:  .:.||..:.|...|.|.:|
  Fly   359 LTYEAIMGMKYLDQVVNEVLRKWPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDP 423

Mouse   422 KVWPNPEVFDPSRFAPDSPR--HSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLP-DP 483
            |.:.||..|||.||:.::..  ...::.||..|.|||||.:||:.|.|.::...|..:...| ..
  Fly   424 KYFENPMKFDPERFSDENKESIQPFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKK 488

Mouse   484 TRVPMPL--ARLVLKSKNGIYLHL 505
            :.:|:.|  :...|..|.|.::.|
  Fly   489 SCIPLELITSGFQLSPKGGFWIKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	119/475 (25%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	119/475 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900