DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a10 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	133/543 - (24%)
Similarity:	237/543 - (43%)	Gaps:	103/543 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 QVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHEKFKGD-QELQEIVSCIENFPS 83
            |||  :.||.:|.    :|:||:  |..|::...|    |......:|: :|||:..:..|.|..
  Fly     9 QVA--VALLAILT----YYIHRK--LTYFKRRGIP----FVAPHLIRGNMEELQKTKNIHEIFQD 61

Mouse    84 AFPRWFWGSKAYLT-----------VYDPDYMKVIL---------------GRSDPKANGAYRLL 122
            .:.: |..|||...           |.|.:..|.||               .:.||
  Fly    62 HYNK-FRESKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDP--------- 116

Mouse   123 APWIGYGLLLLNGQPWFQHRRMLTPAF---HYDILKPYVKNMADS-IRLMLDKWERLADQDSSIE 183
               |...|..|:|..|...|..|:..|   ...::.|.|.::|:. :.:|.:|    ..::|.:|
  Fly   117 ---ISAHLFNLDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEK----VPKNSVLE 174

Mouse   184 IFQHISLMTLDTVMKCAFSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNG 248
            |...::..|:|.:..|||..:.:...|............|.:..|..:.|.|        :.|..
  Fly   175 IRDLVARFTVDVIGTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGF--------MRSYP 231

Mouse   249 RLAKQACQLAHDHTDGVIK----LRKDQLQDEGELEKIKKK---RRLDFLDILLFAR------ME 300
            :||::.         |:::    :::...:...|...:::|   :|.||:|:|:..:      :|
  Fly   232 KLARKL---------GMVRTAPHIQEFYSRIVTETVAVREKEHIKRNDFMDMLIELKNQKEMTLE 287

Mouse   301 NGD---SMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGD-GSSIT 361
            |||   .::.:::.|:...|...|.:|::|.:.:..|.||.:||.|.:.|.||:.::.. ..:.|
  Fly   288 NGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFT 352

Mouse   362 WDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRS--LPKGVQVTLSIYGLHHNPKVW 424
            ::....:.|....:.|.||||..||.:.|..:.....|...:  :..|..|.:....:||:|.::
  Fly   353 YECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIY 417

Mouse   425 PNPEVFDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVP 487
            |.|..|.|.||:|:  :.|.|.::|||..|.|||||.:|...:.::.:||.:..|: ....::.|
  Fly   418 PEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFK-FSTCSKTP 481

Mouse   488 MPLA----RLVLKSKNGIYLHLK 506
            .||.    ..||..|:||||.::
  Fly   482 NPLVYDPKSFVLGVKDGIYLKVE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	120/506 (24%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	120/498 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900