DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a10 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	126/542 - (23%)
Similarity:	224/542 - (41%)	Gaps:	97/542 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    24 VLGLLLLLVKAVQFYLHRQW--LLKAFQQFPSP---PFH------------------WFFGHEKF 65
            |..:||.:|..:..||..:|  .|..:|....|   | |                  |...:.||
  Fly     3 VYSVLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEP-HILMGSLTGVQTSRSFSAIWMDYYNKF 66

Mouse    66 KGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDPK--ANGAYRLLA--PWI 126
            :|              ...|..::|..:..:.|.|....|:||.:...|  ..|.|....  |..
  Fly    67 RG--------------TGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLS 117

Mouse   127 GYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHISLM 191
            |. |.||:||.|...|..|:..|....:|.....:.......::.:.:..::...:|:...::..
  Fly   118 GQ-LFLLDGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARF 181

Mouse   192 TLDTVMKCAF--------SHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNI---FHQNDTIYKLS 245
            |.|.:..|||        ..:...:|.|....:.|..|.:...|.:..:|:   .|...|:.:.
  Fly   182 TTDVIGTCAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEA- 245

Mouse   246 SNGRLAKQACQLAHDHTDGVIKLRKDQLQDEGELEKIKKK---RRLDFLDILL------FARMEN 301
                          :|.         .|:...|....::|   ||.||:|.|:      ..:.|:
  Fly   246 --------------EHF---------FLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSES 287

Mouse   302 GDS--MSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGD-GSSITWD 363
            |:|  ::.:::.|:...|...|.:|:::.:.:..|.||.|.|.|.|.|:|.|.::|. ...||::
  Fly   288 GESVNLTIEEMAAQAFVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYE 352

Mouse   364 HLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRS--LPKGVQVTLSIYGLHHNPKVWPN 426
            .:..:.|....|.|.||||..:|.:.||.......|....  :.||:.|.:....:|.:.|::.|
  Fly   353 SMKDMVYLDQVISETLRLYTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYAN 417

Mouse   427 PEVFDPSRFAPD--SPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFEL-LPDPTRVPM 488
            |..|:|..|:|:  ..|.|..:|||..|.|||||.:|...:.:..:||.:.||:. :.:.|.:|:
  Fly   418 PNTFNPDNFSPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPI 482

Mouse   489 PLAR--LVLKSKNGIYLHLKKL 508
            ..::  .::.|:.||:|.::::
  Fly   483 VYSKKTFLISSETGIFLKVERV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	116/505 (23%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	116/503 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900