DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4a10 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	161/548 - (29%)
Similarity:	261/548 - (47%)	Gaps:	93/548 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    25 LGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFG--HEKFKGDQELQEIVSCIENFPSAFPR 87
            |.|.||||..::....|:  .:...:|..|......|  |:..|...|:.:.|         |..
  Fly     9 LALPLLLVAYLELSTFRR--RRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTV---------FSW 62

Mouse    88 W---------FW-GSKAYLTVYDPDYMKVILG------RSDPKANGAYRLLAPWIGYGLLLLNGQ 136
            |         || |:.:.:.|....|::.||.      :||     .|:|..||:|.|||...|.
  Fly    63 WHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTGS 122

Mouse   137 PWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHISLMTLDTVMKCAF 201
            .|.:||:|:|||||::||:.:.:.|.::....:...:.:|..|:..:..:....:|||.:  |..
  Fly   123 KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI--CDT 185

Mouse   202 SHKGSVQ-VDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHTDGV 265
            :...|:. ::....:.:||..|:....:.|..:...:|:.:|:|:.:.....:..:...|.|:.:
  Fly   186 AMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEI 250

Mouse   266 IKLRKDQLQDEGELEKIKK------------KRRLDFLDILLFARMENGDSMSDKDLRAEVDTFM 318
            |..|         :|..|.            ::::.|||.||.:.:: |..::.|:|..||.|||
  Fly   251 IAKR---------IEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTID-GRPLNSKELYEEVSTFM 305

Mouse   319 FEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGD---GSSITWDHLDQIPYTTMCIKEALR 380
            |||||||.||||:..|.|:.|.|.|::..:|.:.::|:   |...|:..:.|:.|..:.||||.|
  Fly   306 FEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQR 370

Mouse   381 LYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHS 445
            :||.||.|.|........ ||..:|||..:.|.:..|.:|.||:.:|..|.|.||..:.| ....
  Fly   371 VYPSVPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKP-GPFE 433

Mouse   446 FLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLP--------------------------DPT 484
            ::|||.|.|||||::||:.|:|.:|:..:..||:||                          ||.
  Fly   434 YVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPY 498

Mouse   485 R---VPMPLARLVLKSKNGIYLHLKKLH 509
            |   .|:..|.|.|||:||:|:.||:.|
  Fly   499 RHKYDPILSAVLTLKSENGLYIRLKERH 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	149/513 (29%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	136/461 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845140
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640