DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4a10 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	183/509 - (35%)
Similarity:	275/509 - (54%)	Gaps:	42/509 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 LSGFLQVASVL--GLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHEKFKGD-----QELQ 72
            :|....||.||  ..|..|.|.:.| |..|...|.   .|.|.......:.| ||:     :||:
  Fly     1 MSTLALVAFVLWAAFLRYLPKILNF-LRLQRFAKT---LPGPTIGELIANVK-KGEILNWLKELR 60

Mouse    73 EIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSD--PKANGAYRLLAPWIGYGLLLLNG 135
            |     ::.| .|..|| |....:...||:.:|.:||.:.  .|:.. |.||.||:|.|||...|
  Fly    61 E-----KHGP-VFRIWF-GKDLMVMFTDPEDIKQLLGNNQLLTKSRN-YELLEPWLGKGLLTNGG 117

Mouse   136 QPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHISLMTLDTVMKCA 200
            :.|.:.|::|||.||:.||..:.:.|.::.|:::.:....|:.: |.:|:.:|:|..||.:.:.|
  Fly   118 ESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGE-SFDIYPYITLFALDAICETA 181

Mouse   201 FSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHTDGV 265
            ...|...|:..: ..|:||:..:..:.|.:..:.:.:.:..:|.:..|:..:.|.::.||.|:.|
  Fly   182 MGIKKHAQLQSD-SEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRV 245

Mouse   266 IKLRKDQL-------QDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHD 323
            |:||::||       :.|.|.:.:..||||.|||:||..:||.|..:||.|:|.|||||||||||
  Fly   246 IRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHD 310

Mouse   324 TTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGI 388
            ||:|.:::....|:.:||.|||..||...|.|       ...:.:||....|||.||:||.||..
  Fly   311 TTSSAIAFALSLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYPSVPFF 368

Mouse   389 VRELSTSVTFPDGR-SLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRF-APDSPRHSHSFLPFSG 451
            .|::...:..  |: ::|||..::..||.||.:||.:|:||.|||.|| ..:...|..:|..||.
  Fly   369 SRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSA 431

Mouse   452 GARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKSKNGIYLHL 505
            |.|||||::|||.|||..:|:.|..:..|||....|.|||.||.||.|||.|.:
  Fly   432 GPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRI 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	170/466 (36%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	160/453 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844982
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640