DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp46a1 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_034140.1	Gene:	Cyp46a1 / 13116	MGIID:	1341877	Length:	500	Species:	Mus musculus
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	141/506 - (27%)
Similarity:	249/506 - (49%)	Gaps:	70/506 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 LLLGSAVLLAFGLCCTFVHRA----RSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFLD 66
            :||...|:|.|| ....:|..    |.:..::|||..|. |:|.:....:.:.   :....|..:
  Fly     1 MLLFLLVVLLFG-AGWIIHLGQADRRRKVANLPGPICPP-LIGAMQLMLRLNP---KTFIKVGRE 60

Mouse    67 WAKKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECDY 131
            :..|:|.:.||.:|.:..::....|..::.|.|.::.....:|:    |.|:.| |.||:.. |.
  Fly    61 YVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYK----VLGQWL-GNGLLLS-DG 119

Mouse   132 GRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDILAKAA 196
            ..|:::||::...|..|.|...:|.|::::...|:.|..||:|.| ..:...:..|.:||:|:.|
  Fly   120 KVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNT-FDVYRSICAAALDIIAETA 183

Mouse   197 FGMETSMLLGAQKPLSQAVK--------------VMLEGISASRN------------TLAKF--- 232
            .|.:.........|.::||.              :.:|.:....:            |:.:|
  Fly   184 MGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIK 248

Mouse   233 MPGKRKQLREIRESIRLLRQVGKDWVQRRREALKRGEDMPADILTQILKAEEG--AQDDEVLLDN 295
            :..||:|..|.::| :|:....:|...:||.||       .|:|  ::...:|  ..:||: .:.
  Fly   249 VIEKRRQALEDQQS-KLMDTADEDVGSKRRMAL-------LDVL--LMSTVDGRPLTNDEI-REE 302

Mouse   296 FVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGS--KRHLDYEDLGRLQYLSQVLK 358
            ..||...||:|:.:.|:|.:.||||.||:.|::..|:.:|:|:  .|.:...|||.|:|:..|:|
  Fly   303 VDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIK 367

Mouse   359 ESLRLYPPAWGTFRLLEEETLI------DGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG 417
            ||||:|||.....|.|:.:...      ||| :|..:.::...:.:.|....|.:|..|.|:|..
  Fly   368 ESLRMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPERHE 431

Mouse   418 PGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVP-GQR 467
            .|:....|...|||.|.|:||||:|||:|:|:::||:::  |:.|:| |||
  Fly   432 NGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR--EYELLPMGQR 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	130/471 (28%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	125/436 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810