Protein Alignment Cyp46a1 and Cyp316a1

DIOPT Version :10

• Sequence 1: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Sequence 2: NP_648129.2
• Gene: Cyp316a1 / 38840
• FlyBaseID: FBgn0035790
• Length: 484
• Species: Drosophila melanogaster
• Alignment Length: 519
• Identity: 116/519 - (22%)
• Similarity: 211/519 - (40%)
• Gaps: 89/519 - (17%)

Mouse    10 SAVLLAFGLCCTF----VHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFL----- 65
            :|..:.|.|...|    ..|.||..:::.|           |:.|..   .|.:.:.:||
  Fly     4 TATFICFCLASAFNYFRARRQRSLIKNLKG-----------PFTWPL---MGAMHKLLFLTPINF 54

Mouse    66 -----DWAKKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGL 125
                 ::..|||...|..||::..:.:...|..::.|.:..:         |:|  |..|....|
  Fly    55 FQRSTEYLTKYGTFSRCWVFHRLFIPLADLELSRQLLENDTH---------LET--GYELMKDWL 108

Mouse   126 VS---ECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCA 187
            |.   .|...:|.|:..::...|.:.:|..|::....:.|||::.|..:|| |....:...::..
  Fly   109 VGGVLMCQSEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQAD-QKVFDIWYTVSPI 172

Mouse   188 TIDILAKAAFGMETSMLLGAQ-KPLSQAV-KVMLEGISASR--------------NTLAKFMPGK 236
            .:|::.....|.:.|...... |.||:.. |..|...||:|              |.|.|.:..:
  Fly   173 VLDLMVMTTCGAKPSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDE 237

Mouse   237 RKQLREIRESIRLLR-QVGKDWVQRRREALKRGEDMPADILTQILKAEEGAQDDEVLLDNFVTFF 300
            ...|..:.:|...|: :.|.|..|.|...||..:    .:|..:|::::.....|.:.....|..
  Fly   238 HNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHK----SLLEILLESKDPQLTGEEICGELNTCN 298

Mouse   301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRLYP 365
            ..|::..:..|.|.::.::|.|.:   .|..:||:..::......||.:|.||..||.|::||||
  Fly   299 YLGYQLCSPALCFCLVTIARNPSV---QQKCLDELNLAQIKDQGWDLEKLNYLDAVLHETMRLYP 360

Mouse   366 PAWGTFRLLEEE-----TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRF 425
            |.....|.|:::     :::....:|..:.:..:.|.:.|.:..:.....|:..||....|:
  Fly   361 PQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFLDSPPE--- 422

Mouse   426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ-----------RIEFRLVPGQRFGLQEQATLKP 478
             ...:|||.|.|..::|:...:|.::|.:|.           |::.|||.|...|.  |..|||
  Fly   423 -LLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLRLVLGSSNGF--QLALKP 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp46a1	NP_034140.1	CYP46A1-like	61..484	CDD:410706	105/464 (23%)
Cyp316a1	NP_648129.2	cytochrome_P450	70..479	CDD:477761	96/433 (22%)