DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp46a1 and Cyp4d20

DIOPT Version :9

Sequence 1:	NP_034140.1	Gene:	Cyp46a1 / 13116	MGIID:	1341877	Length:	500	Species:	Mus musculus
Sequence 2:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	146/541 - (26%)
Similarity:	240/541 - (44%)	Gaps:	96/541 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 LLLGSAVLLA---FGLCCTFVHRARSR---YEH--IPGP---PRPSFLLGHLPYFWKKDEDCGRV 59
            |:.|:.:||.   ||       |.|.|   :|.  ||||   |    :||           ||
  Fly     5 LITGALILLLTWDFG-------RKRQRVLAFEKSAIPGPISIP----ILG-----------CG-- 45

Mouse    60 LQDVFL------DWA----KKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQT 114
            ||.:.|      .|.    .|||...|..:..::.:.....:..:..|.||...:..::|..|:.
  Fly    46 LQALHLGAENIIGWVGEKFDKYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRP 110

Mouse   115 VFGERLFGQGLVSECDYGR-WYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPV 178
            ...:.|    |||.   || |:.:||:...||....|...:|..:..:..:|:.|...|||:|.|
  Fly   111 FLNDGL----LVST---GRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAV 168

Mouse   179 SMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNTLAKF-------MPGK 236
            .|...::.|.:|::.:||.|::.:.......|..:|:|.:   :....:.:.:|       .|..
  Fly   169 DMLKYVSLAALDVITEAAMGVQVNAQNDPDFPYIKALKSV---VYIQPDRMFRFSRRYNWLFPLA 230

Mouse   237 RKQL-REIRESIRLLRQVGKDWVQRRREALKRGEDMPADILTQILK---AEEGAQDDEVLLDNFV 297
            ...| |::...||::.......:..|||.::|.:   ||...:.|.   ||.|::....|||..:
  Fly   231 APLLHRQLLSDIRVMHDFTDKVISERRETVRRAK---ADGTYRPLSLGDAEIGSKSQMALLDILL 292

Mouse   298 -------------------TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVG--SKRH 341
                               ||...|.:|:::.::..:..::|.||:..|:..|:..|:|  :...
  Fly   293 QSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAP 357

Mouse   342 LDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFE 406
            :....|..|:||..|:||::|||||.....|..::|..|....:|.||.:....|...|...||.
  Fly   358 VTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFP 422

Mouse   407 DPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVP-GQRF 468
            |||:|.|:||.....:..  |.|.|||.|.::||||:||.:|:||:::|:|:..|  |:| |:..
  Fly   423 DPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYE--LLPLGEEL 485

Mouse   469 GLQEQATLKPLDPVLCTLRPR 489
            .......|:....:...||||
  Fly   486 KPMLNFILRSASGINVGLRPR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	129/480 (27%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	130/490 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910