Protein Alignment Cyp46a1 and Cyp4ac3

DIOPT Version :9

• Sequence 1: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Sequence 2: NP_608918.1
• Gene: Cyp4ac3 / 33756
• FlyBaseID: FBgn0031695
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 122/540 - (22%)
• Similarity: 219/540 - (40%)
• Gaps: 143/540 - (26%)

Mouse     5 LLLLGSAVLLA---------------FGLCCTFVHRAR--------SRYEHIPGPPR-------- 38
            :.||||::|:.               ..||    .|.|        |:...:||..|
  Fly     3 IALLGSSLLIGALWLLLRQLNKTYFILSLC----KRVRTADGSPLESKVFVVPGKTRFGNNLDLL 63

Mouse    39 ---PSFLLGHL----------PYFWKKDEDCGRVLQDVFLDWAKKYGPVVRVNVFYKTSVIVTSP 90
               |:.:..::          .|.|.            || :|.:|. :||.
  Fly    64 NLTPANIFSYIRESTAKANGQNYIWN------------FL-FAPEYN-IVRA------------- 101

Mouse    91 ESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECDYGRWYKQRKVMDLAFSRSSLVSLME 155
            |..::...|||....:..|..::...|:     ||:...|. :|:.:||.:..||..:.|.|.:.
  Fly   102 EDAEEIFQSTKITTKNMSYELIRPFLGD-----GLLISIDQ-KWHTRRKTLTPAFHFNILQSFLS 160

Mouse   156 TFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLE 220
            .|.|::::.::||:.....:  :.:..::...|::.:.:.|.|::              :..|.|
  Fly   161 IFKEESKKFIKILDKNVGFE--LELNQIIPQFTLNNICETALGVK--------------LDDMSE 209

Mouse   221 GISASRNTLAK------------------------FMPGKRKQLREIRESIRLLRQVGKDWVQRR 261
            |     |...|                        |:.|..|:...|   :|.:.......:||:
  Fly   210 G-----NEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRI---LRTIHGFSSGIIQRK 266

Mouse   262 REALKR---------GEDMPADILTQILKAE-EGAQDDEVLLDNFVTFFIAGHETSANHLAFTVM 316
            |:..|:         |:.....:|..:|.|| ||..|.:.:.|...||...|::|::..|.||::
  Fly   267 RQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEGKIDHQGICDEVNTFMFGGYDTTSTSLIFTLL 331

Mouse   317 ELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLID 381
            .|:...::..|...|:.::......:.......|.:|..|:||||||:|.|....|...||::::
  Fly   332 LLALHADVQERCYEELQDLPEDIDEVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMN 396

Mouse   382 GVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQ 444
            |:.:|.|..:....|.:.|...:|..|..|.|:||.|  ...:..|.:.|||.|.|:||||:|..
  Fly   397 GLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGV 461

Mouse   445 MEVKVVMAKLLQRIEFRLVP 464
            :|:||::|.:::  .|:|:|
  Fly   462 LEIKVLLAAVIR--NFKLLP 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	112/488 (23%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	112/488 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000