Protein Alignment Cyp46a1 and Cyp4s3

DIOPT Version :9

• Sequence 1: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Sequence 2: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 135/494 - (27%)
• Similarity: 222/494 - (44%)
• Gaps: 70/494 - (14%)

Mouse     8 LGSAVLLAFGLCCTFVH---------RARSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDV 63
            :.:..|:||.|...|:.         |.:...:.:|||     .:|.|....||.|
  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGP-----TIGELIANVKKGE--------- 51

Mouse    64 FLDWAK----KYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 124
            .|:|.|    |:|||.|:.......|:.|.||.:|:.|.:.:....|:.|..|:...|:.|...|
  Fly    52 ILNWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNG 116

Mouse   125 LVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATI 189
            ..|      |:::||::...|....|....|...|....||..|..||:|:: ..:...:|...:
  Fly   117 GES------WHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFAL 174

Mouse   190 DILAKAAFGMETSMLLGAQKPLSQAV----KVMLEGISASRNTLAKFM----PGKRKQ--LREIR 244
            |.:.:.|.|::....|.:.....|||    :||.:...:....|..|.    |||.::  |:.:.
  Fly   175 DAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLH 239

Mouse   245 -ESIRLLRQVGKDWVQRRREALKRGE--DMPAD---------ILTQILKAEEGAQ-DDEVLLDNF 296
             |:.|::|...:..:|.|.|.....|  |:.|.         :|||:   |.||: .|..:.:..
  Fly   240 DETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQM---EGGAELSDTDIREEV 301

Mouse   297 VTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESL 361
            .||...||:|:::.:||.:..||:.|::..|...|..|:.|.::.       .:.||..|:||:|
  Fly   302 DTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREKE-------SMPYLEAVIKETL 359

Mouse   362 RLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR-F 425
            |:||......|.:.|:..:..:.||....:....|::.|....|.||..|:||||.....:.. |
  Fly   360 RIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPF 424

Mouse   426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVP 464
            .:..||.|.|:||||:||.:|:|..:|.||:  .:|.:|
  Fly   425 AFAAFSAGPRNCIGQKFAMLELKTSLAMLLR--SYRFLP 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	129/459 (28%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	129/460 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810