DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp27b1 and Cyp12a4

DIOPT Version :9

Sequence 1:	NP_034139.2	Gene:	Cyp27b1 / 13115	MGIID:	1098274	Length:	507	Species:	Mus musculus
Sequence 2:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	134/522 - (25%)
Similarity:	229/522 - (43%)	Gaps:	83/522 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    35 RSLSDIPGPSTLSFLAELFCKGGLSRLHEL-QVHGAAR--YGPIW--SGSFGTLRTVYVADPTLV 94
            :....||..:..:...::...||..:..|| ::..|.|  ||.|:  .|..|....:...:|...
  Fly    45 KPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDF 109

Mouse    95 EQLLRQESHCPERCSFSSWAEHRRR-----HQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGY 154
            |.:.|.|...|.|....:...||..     :|...|::...|:.|...|:::.|:|::|:....|
  Fly   110 EVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLY 174

Mouse   155 AGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFY----KFGLESIGAVLLGSRLGCLE-AEV 214
            ...:..|.::.|:|:...|...:      |:...:|.    ::.|||:..|.|..:||.|: :..
  Fly   175 YKKMSQVNQEFVQRILELRDPDT------LEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNK 233

Mouse   215 PPDTETFIHAVGSVFVSTL-LTMAMPNWLHHLIPGPW--------ARLCRDWDQM----FAFAQR 266
            ..:.....|.:...|:.:: |.|.         |.||        .||.|..|.:    .|:...
  Fly   234 ESEALKLFHYLDEFFIVSIDLEMK---------PSPWRYIKTPKLKRLMRALDGIQEVTLAYVDE 289

Mouse   267 HVELREGEAAMRNQG--KPEEDMPSGHHLTHFLFREKVSVQSIVGNV--TELLLAGVDTVSNTLS 327
            .:|..:.||   .:|  :||.:..        :..:.:.|...|..|  .::|:|||||.|:|.:
  Fly   290 AIERLDKEA---KEGVVRPENEQS--------VLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFT 343

Mouse   328 WTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDR 392
            ..|..|:::|:.|..|..|:........:.....::..:|.|:|.|||..||:|::.||:||..|
  Fly   344 ALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLAR 408

Mouse   393 DIRVGNYVIPQDTLVSLCHY-ATSRDPTQFPDPNSFNPARWL-----GEGPTP-------HPFAS 444
            |..:..|.:|..|.|::... |.:|| ..||..:.|.|.|||     .|...|       :||..
  Fly   409 DAVLSGYRVPAGTYVNIVPLNALTRD-EYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVF 472

Mouse   445 LPFGFGKRSCIGRRLAELELQMALSQILTHFEV---LPEPGALPIKPMTRTVLV--PERSINLQF 504
            ||||||.|.|:|:|:.|:||::..::::.:|.|   .|...|.      |:.|:  |...:..:|
  Fly   473 LPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAF------RSALINLPNIPLKFKF 531

Mouse   505 VD 506
            :|
  Fly   532 ID 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp27b1	NP_034139.2	p450	41..504	CDD:278495	131/512 (26%)
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	128/491 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.880