DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp27b1 and Cyp12b2

DIOPT Version :9

Sequence 1:	NP_034139.2	Gene:	Cyp27b1 / 13115	MGIID:	1098274	Length:	507	Species:	Mus musculus
Sequence 2:	NP_611370.2	Gene:	Cyp12b2 / 37163	FlyBaseID:	FBgn0034387	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	141/489 - (28%)
Similarity:	225/489 - (46%)	Gaps:	46/489 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse    35 RSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAAR--YGPIW--SGSFGTLRTVYVADPTLVE 95
            ||..:|||||.|..|:.....|.|...:.:|::...|  ||.|:  .|..|....|:..:|...|
  Fly    51 RSFGEIPGPSLLRMLSFFMPGGALRNTNLIQMNRLMREMYGDIYCIPGMMGKPNAVFTYNPDDFE 115

Mouse    96 QLLRQESHCPERCSFSSWAEHRRRHQ----RACGLLTAD-GEEWQRLRSLLAPLLLRPQAAAGYA 155
            ...|.|...|.|....|...:|:.|:    :..|.|.:| |:||..:|:.:.|:|::.|......
  Fly   116 MTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVLMKVQNVRQNL 180

Mouse   156 GTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTET 220
            ..||.:.::.:.:|..||...:..  |..|...:...:..|||..|.|.:|:|.|.....|:.:.
  Fly   181 PQLDQISKEFIDKLETQRNPETHT--LTTDFHNQLKMWAFESISFVALNTRMGLLSDNPDPNADR 243

Mouse   221 FIHAVGSVFVSTLLTMAMPN-WLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPE 284
            ....:...|..:......|: |..:...| :.:..:.:|.:......::     |.|||..|| .
  Fly   244 LAKHMRDFFNYSFQFDVQPSIWTFYKTAG-FKKFLKTYDNITDITSNYI-----ETAMRGFGK-N 301

Mouse   285 EDMPSGHHLTHFL-FREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSE-- 346
            :|..:...|...| ..:||:|..::    ::|:||:||.|:.....||.|:|:|..|..|..|
  Fly   302 DDGKTKCVLEQLLEHNKKVAVTMVM----DMLMAGIDTTSSACLTILYHLARNPSKQEKLRRELL 362

Mouse   347 -ITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLC 410
             |...|:.|....:   ...:|.|:|.|||.||:..:.|||.|:..:|:.:..|.:|:.|.|.:.
  Fly   363 RILPTTKDSLTDQN---TKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQVPRGTGVLMG 424

Mouse   411 HYATSRDPTQFPDPNSFNPARWLGEGPTP-----------HPFASLPFGFGKRSCIGRRLAELEL 464
            ....|.|...|...:.|.|.|||.....|           :||..||||||.|:|||:|:||||:
  Fly   425 VLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPAARTRNPFVYLPFGFGPRTCIGKRIAELEI 489

Mouse   465 QMALSQILTHFEV--LPEPGALPIKPMTRTVLVP 496
            :..|.::|..::|  |||   .||:..:..:|.|
  Fly   490 ETLLVRLLRSYKVSWLPE---TPIEYESTIILSP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp27b1	NP_034139.2	p450	41..504	CDD:278495	138/483 (29%)
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	133/470 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	1	0.950	-	0	Normalized mean entropy	S4820
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.830