DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a16 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	180/545 - (33%)
Similarity:	289/545 - (53%)	Gaps:	92/545 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 TLVLLAIILVLL--------YRYGTCTHGLFKKQGIPGPK--PLPF--LGTVLNYYKGLWKFDME 63
            :|:|||:.|:.|        |.|       ::::|.|..|  .:||  |.:|....|.:   .:.
  Fly     3 SLILLAVTLLTLAWFYLKRHYEY-------WERRGFPFEKHSGIPFGCLDSVWRQEKSM---GLA 57

Mouse    64 CYEKYGKT----WGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFFPVGI--------MSK 116
            .|:.|.|:    .|::....|..:|.|.:..:.||.:: |:.|.:|      |:        :|.
  Fly    58 IYDVYVKSKERVLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDR------GVYVDEERDPLSA 115

Mouse   117 SISLAKDEEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQE-AEKG-KPVAVKDVLGAY 179
            :|...:.:.|:..|.:|||.||||.||.||...|..||.:|.:|::| .|:| |.|.:|.|:..|
  Fly   116 NIFSLRGQSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNY 180

Mouse   180 SMDVIISTTFGVNIDSLNNPEDPF---VENAKKVLRFDYFDPLSL----SVALFPFLTPIYEMLN 237
            ::|:|.||.||::::|..||::.|   |..|:...||:....:.:    |:|.|.|.......:.
  Fly   181 AIDIIASTIFGLDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVG 245

Mouse   238 ICMFP--KDSIEFFKKFVDRMTENRLDSKQKH---RVDFIYLMMEAYN---------KS----KD 284
            :.|..  |:::|:               ::||   |.|.:.|:::..|         ||    |.
  Fly   246 LAMLQIVKETVEY---------------REKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKT 295

Mouse   285 KDSH-KALSEIEITAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEAL-PNKAPPT 347
            .|.| |.:|...||||:.||..||.|||.|..:||:|.||.:|::.|:||:|:||.| .|....|
  Fly   296 PDGHIKTISLEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKIT 360

Mouse   348 YDTVMAMEYLDMVLNETLRLYPITNRLQRVCKKDVEI---NGIYIPKGSTVIIPSYVLHHDPQHW 409
            ||::..||:||:.:.||:|.||....|.|.|.:|..:   |.: ||||:.|:|..|.:|||.:::
  Fly   361 YDSLNKMEFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYF 424

Mouse   410 PEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQI 474
            |:||.:.|||||:|:: :.:|..::|||.|||.||..|...:|.|||:||:||||:.:....::|
  Fly   425 PDPETYDPERFSEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI 488

Mouse   475 PLKLSRELLL--QPVKPIVLKVVPR 497
            ..:.|...|:  ..|:..:.|.||:
  Fly   489 EFENSGIALIPKHGVRVRLSKRVPK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	168/504 (33%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	160/465 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820