DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a16 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	174/522 - (33%)
Similarity:	283/522 - (54%)	Gaps:	50/522 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse    14 LLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGTVLNYYKGLWK---FDMEC--YEKYG--KT 71
            |.||...|.||:.:..:..||.:||...||:.:.|.:...:  |.|   ||:.|  |.|.|  |.
  Fly     8 LFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMF--LRKRAMFDIVCDLYTKGGSKKF 70

Mouse    72 WGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFFPV----------GIMSKSISLAKDEEW 126
            :|:|:.:.||.::.||:.||.:.:|: |..|.|.::.|..          .:...|:...:|..|
  Fly    71 FGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDARW 134

Mouse   127 KRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEK--GKPVAVKDVLGAYSMDVIISTTF 189
            |..|:.|||.||...:::||.::.|.....|..|:|:..:  ...:.:||....::.|||.||.|
  Fly   135 KDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENELDMKDYCTRFTNDVIASTAF 199

Mouse   190 GVNIDSLNNPEDPFVENAKKVLRFDYFDPLSLSVALFPFLTPIYEMLNICMFPKDSIEFFKKFVD 254
            |:.::|..:.|:.|.:..||:..|.:..  |:...||..|..:.::|.:.:|.:.|.::|.:.|
  Fly   200 GLQVNSFKDRENTFYQMGKKLTTFTFLQ--SMKFMLFFALKGLNKILKVELFDRKSTQYFVRLV- 261

Mouse   255 RMTENRLDS---KQKH---RVDFIYLMMEA---YNKSKDKDSH-KALSEIEITAQSIIFIFAGYE 309
                  ||:   :|:|   |.|.|.::|||   ....|.|.|. :..|:.:|.||..:|.|||:|
  Fly   262 ------LDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFE 320

Mouse   310 TTSSILSFTVYSLATHPDIQKKLQEE---IDEALPNKAPPTYDTVMAMEYLDMVLNETLRLYPIT 371
            |::.::.||.:.|..:.|:|::|.||   :|:.|..| ..||:.:|.|:|||.|:||.||.:|..
  Fly   321 TSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLRKWPAA 384

Mouse   372 NRLQRVCKKDV--EING--IYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYV 432
            ..:.|.|.||:  :::|  :.:.||..:.:|:...|.||:::..|.:|.|||||.|||.||.|:.
  Fly   385 IAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFT 449

Mouse   433 YLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKL-SRELLLQPVKPIVLKVVP 496
            |.|||.|.|||||.||||:..|..:..:|:::.|.|.|::.|||:| :....|.|.....:|:|.
  Fly   450 YFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKLVQ 514

Mouse   497 RD 498
            |:
  Fly   515 RN 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	161/491 (33%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	161/486 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770