DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a16 and Cyp6a23

DIOPT Version :9

Sequence 1:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus
Sequence 2:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	175/501 - (34%)
Similarity:	279/501 - (55%)	Gaps:	26/501 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 LVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGTVLNYYK--GLWKFDMECYEKYGKTWGL 74
            |.|:|:::.||.......||.::::|||...|.|..|.:.::.|  .:.....:.|.||.::...
  Fly     5 LTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRSVYP 69

Mouse    75 FDGQIPLF----VITDPETIKNVLVKECFSVFTNRQDFF-----PVGIMSKSISLAKDEEWKRYR 130
            |.|....|    ||||.|.:|.||:|: |:.|.||..|:     |   :|.::...:.::|:..|
  Fly    70 FAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDP---LSATLFSIEGQKWRHLR 130

Mouse   131 ALLSPTFTSGNLKEMFPVIEQYGDILVKYL--RQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNI 193
            ..|:||||||.:|.|||:|.:.|:.:.|..  :....:|:.:.:.|::..|:.|||.:..||:|.
  Fly   131 HKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNC 195

Mouse   194 DSLNNPEDPFVENAKK-VLRFDYFDPLSLSVALFPFLTPIYEMLNICMFPKDSIEFFKKFVDRMT 257
            :||.||...||...|: ::...|...|...:..||.|:   ..|.:.:..:|..:|:...|....
  Fly   196 NSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLS---RRLRLKLNVQDVEDFYTSIVRNTI 257

Mouse   258 ENRLDSKQKHRVDFIYLMMEAYNKSKDKDSHKALSEIEITAQSIIFIFAGYETTSSILSFTVYSL 322
            :.||.:.:| |.||:..::|.|.|.:..::...||..||.||:.||..||:||:|:.:.|.:|.|
  Fly   258 DYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYEL 321

Mouse   323 ATHPDIQKKLQEEIDEAL-PNKAPPTYDTVMAMEYLDMVLNETLRLYPITNRLQRVCKKDV--EI 384
            |...|||.:|:.||:..| .:....||:.:..|:||:.|:.||||.||:...|.|:.:.|.  |.
  Fly   322 ALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPED 386

Mouse   385 NGIYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFA 449
            ...:|.||:||:||:..:|:||:.:||||:|:||||:.|...:.....:||||.|||||||:||.
  Fly   387 PKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFG 451

Mouse   450 LMNMKLALIKVLQNFSFQPCKETQIPLK-LSRELLLQPVKPIVLKV 494
            ||...:.|..:::.:.|....|||||:| :.:.:||.....|.|||
  Fly   452 LMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKV 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	164/472 (35%)
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	162/466 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3433
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.670