DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a16 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	170/531 - (32%)
Similarity:	278/531 - (52%)	Gaps:	58/531 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 SLDTLVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGTV-LNYYKG---LWKFDMECYEKY 68
            |:..|.|..|:|||||::....:.:|.::|:...||.|.:|.: |....|   :.|..:|.:.|:
  Fly     4 SMIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTKH 68

Mouse    69 --GKTWGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDF---FPVGIMSKSISLAKDEEWKR 128
              ...:|::..:..:|.:.|||.||.:.:|| |..|.|....   ....|:|||:...:|..||.
  Fly    69 TGSPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDGRWKE 132

Mouse   129 YRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAV----KDVLGAYSMDVIISTTF 189
            .|.:|:|.||...::.|:.:|:...:..|.:::::.|..:..::    ||....::.|||.:..|
  Fly   133 MRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIATVAF 197

Mouse   190 GVNIDSLNNPEDPFVENAKKVLRFDYFDPL-SLSVALFPFLTPIYEMLNICMFPKDSIEFFKKFV 253
            |::|:|....::.|....:.:.|...:..: ::..||||.|   .::|.|.:....:|::|...|
  Fly   198 GISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRL---MKVLRIQVLDTKNIDYFSSLV 259

Mouse   254 DRMTENRLDSKQKHRV---DFIYLMMEA--------YNKSKDKDSHKALSEIEITAQSIIFIFAG 307
            ......|    |:|:|   |.|:|:|||        .:||||:..:...:..::.||.::|.|||
  Fly   260 TAAMRYR----QEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAG 320

Mouse   308 YETTSSILSFTVYSLATHPDIQKKLQEEI---DEALPNKAPPTYDTVMAMEYLDMVLNETLRLYP 369
            :|..||.|.|..:.|..:|.:|.:|.|||   .|.|..: |.|||.:..|:|||||:.|.||.:|
  Fly   321 FEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVVLEALRKWP 384

Mouse   370 ITNRLQRVCKKDVEI---NG---IYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSI 428
            .:....|.|::|:::   ||   ....||..:.||.:.|||||:::.:||.|.||||:..:  ::
  Fly   385 PSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFADGH--AL 447

Mouse   429 DPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLSRELL-------LQP 486
            :..||:|||.|||||||.|.|||.:|..:.::|.||...|.|.|      ||:||       |:|
  Fly   448 ESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRT------SRDLLNDIRGHGLKP 506

Mouse   487 VKPIVLKVVPR 497
            .....||...|
  Fly   507 KNGFWLKFEAR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	157/495 (32%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	156/490 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.770