DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a16 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	173/503 - (34%)
Similarity:	275/503 - (54%)	Gaps:	34/503 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 LDTLVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGTVLNYYKGL-W-KFDMECYEKY--- 68
            |..|||:..:.:|||......:..:.::|:.|.:|:.|.|.:....:.| | ..::..|.|:
  Fly     2 LTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGV 66

Mouse    69 GKTWGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFFPV--GIMSKSISLAKDEEWKRYRA 131
            .:..|.|........|.|.|.|::::::: ||.|.:|..|..|  ..::.::......||:..|.
  Fly    67 ERYCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLRQ 130

Mouse   132 LLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNIDSL 196
            .|:..||||.:|.|||.:.:.|:.|.:..|.:..:   :..||:...::.|||.|..||:..:||
  Fly   131 NLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGE---IEAKDLCARFTTDVIGSCAFGLECNSL 192

Mouse   197 NNPEDPFVENAKKVLRFDYFDPL-SLSVALFPFLTP-IYEMLNICMFPKDSIEFFKKFVDRMTEN 259
            .:||..|....:.|.:    :|| |:.|..|.|..| :...|...:|..:..|||...| |.|
  Fly   193 QDPESQFRRMGRSVTQ----EPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTV-RQT-- 250

Mouse   260 RLDSKQK---HRVDFIYLMMEAYNKS-KDKDSHKALSEIEITAQSIIFIFAGYETTSSILSFTVY 320
             ||.:::   ||.|.|.|:||...:. ||     |||..:|.||:::|..||::|:|:.:||.:|
  Fly   251 -LDYRRRENIHRNDLIQLLMELGEEGVKD-----ALSFEQIAAQALVFFLAGFDTSSTTMSFCLY 309

Mouse   321 SLATHPDIQKKLQEEIDEALP-NKAPPTYDTVMAMEYLDMVLNETLRLYPITNRLQRVCKKDVEI 384
            .||.:||:|::|:.|:...|. |....|||:|..|.|||.|:.||||.|||...|.|...|:.:|
  Fly   310 ELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQI 374

Mouse   385 --NGIYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCIGMR 447
              :.:.:..||.:|||.:.:||||:.:|:||:|.|.||..|...:..|:.|||||.|||||||.|
  Fly   375 PNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGER 439

Mouse   448 FALMNMKLALIKVLQNFSFQPCKETQIPLKL-SRELLLQPVKPIVLKV 494
            |..:.:|:.|:.:|::|.|...::||||||. ||..|:...:.:.|::
  Fly   440 FGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRM 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	165/471 (35%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	163/459 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720