DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a16 and Cyp9b1

DIOPT Version :9

Sequence 1:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus
Sequence 2:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	158/495 - (31%)
Similarity:	256/495 - (51%)	Gaps:	51/495 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 LDTLVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGTVLNYYKGLWKFDMECYEKYGKT-- 71
            ::..::||.|.:||:::.|.|...|:.:.:...||.||||.:.........|..:..|.|.:|
  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRH 68

Mouse    72 ---WGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDF-FP-VGIMSKSISLAKDEEWKRYRA 131
               .|||:.:.|:..|.||:.||.:.||: |..|.|.|.. .| ..:::..:::.:|:.|:..|:
  Fly    69 HKLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWRNMRS 132

Mouse   132 LLSPTFTSGNLKEMFPVI-EQYGDILVKYLRQEAEKGKPVA---------VKDVLGAYSMDVIIS 186
            :|:|.|||..::.||.:: |.:...|     :..:..:|:|         :|.:....|.|||.:
  Fly   133 VLTPVFTSAKMRNMFTLMNESFAQCL-----EHLKSSQPIAAGENAFELDMKVLCNKLSNDVIAT 192

Mouse   187 TTFGVNIDSLNNPEDPFVENAKKVLRFDYFDP-LSLSVALFPFLTP-IYEMLNICMFPKDSIEFF 249
            |.||:.::|.::||:.| ....|.|.|....| |...:.|   |.| ::....:.:|...::|:|
  Fly   193 TAFGLKVNSFDDPENEF-HTIGKTLAFSRGLPFLKFMMCL---LAPKVFNFFKLTIFDSTNVEYF 253

Mouse   250 KKFVDRMTENRLDSKQKH---RVDFIYLMMEAYNKSKDKDSHKALSEIEITAQSIIFIFAGYETT 311
            .    |:..:.:..::||   |.|.|.|:|||..:|||.     .::.||.||..||.||.:|..
  Fly   254 V----RLVVDAMQYREKHNITRPDMIQLLMEAKKESKDN-----WTDDEIVAQCFIFFFAAFENN 309

Mouse   312 SSILSFTVYSLATHPDIQKKLQEEI---DEALPNKAPPTYDTVMAMEYLDMVLNETLRLYPITNR 373
            |:::..|.|.|..:.|||::|.||:   .|||.. ||.|||....|.|:|||::|:||.:.::..
  Fly   310 SNLICTTAYELLRNLDIQERLYEEVKETQEALKG-APLTYDAAQEMTYMDMVISESLRKWTLSAA 373

Mouse   374 LQRVCKKDVEING------IYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYV 432
            ..|:|.||..:..      .....|..:.||...||.|.:.:|:|:.|.|||||:..|..:.||.
  Fly   374 ADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPYT 438

Mouse   433 YLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKET 472
            |||||.|||:|||.|:|:|..|..|..::.|:..:....|
  Fly   439 YLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRT 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	150/465 (32%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	149/460 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.770