DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp3a16 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	153/533 - (28%)
Similarity:	254/533 - (47%)	Gaps:	73/533 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 SALSLDTLVLLAIIL----------VLLYRYGTCTHGLFKKQGIPGPKPLPFLGTVLNYYKGLWK 59
            :||::.:||||.::|          |.|::.....|  :::.|:|.....||:|.|.|..:|...
  Fly    10 AALAVGSLVLLPVVLRGGCLLVVTIVWLWQILHFWH--WRRLGVPFVPAAPFVGNVWNLLRGACC 72

Mouse    60 FD---MECYEKYGKTWGLFDGQIPL----FVITDPETIKNVLVKECFSVFTNR-QDFFPV--GIM 114
            |.   .|.||........|.|...|    .::.||..||.::|:: |:.|::| :...|.  .:.
  Fly    73 FGDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVED-FAQFSSRFETTDPTCDTMG 136

Mouse   115 SKSISLAKDEEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQE--AEKGKPVAVKDVLG 177
            |:::..:|.|.|:....:.:|.|.:|.::.|:.::|..|..|.:::.|:  ......:.||.:..
  Fly   137 SQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCA 201

Mouse   178 AYSMDVIISTTFGVNIDSLNNPEDPF----VE----NAKKVLRFDYFDPLSLSVALFPFLTPIYE 234
            .::.|:|.|..||:...||.|||..|    :|    ..|::|..       .::..||.|:   .
  Fly   202 LFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHL-------FTMFFFPRLS---H 256

Mouse   235 MLNICMFPKDSIEFFKKFVDRMTENRLDS-KQKHRVDFIYLMMEAYNKSKDKDSHKALSEIE--- 295
            .:...::.::...|.:|.:|.:...|.:| :.:|.:..|:|.:        |.:..|.|.|.
  Fly   257 RVGTHLYSEEYERFMRKSMDYVLSQRAESGENRHDLIDIFLQL--------KRTEPAESIIHRPD 313

Mouse   296 -ITAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEALPNKAPP--TYDTVMAMEYL 357
             ..||:...:.||::|:||.::|.:|.||.:..||.:|:.|:..||.:....  :.|||..:.||
  Fly   314 FFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYL 378

Mouse   358 DMVLNETLRLYPITNRLQRVCKKDVEI-----NG---IYIPKGSTVIIPSYVLHHDPQHWPEPEE 414
            ..|::|.|||||.|..|.|.|......     ||   ..:..|:.|.|....:|.|.|:||.||.
  Fly   379 RQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEV 443

Mouse   415 FQPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLS 479
            |.|||||.|.:....|..|||||.|||.|||.....:.:|:.|:.:|.:|..:.|:.| :|
  Fly   444 FDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERT-LP---- 503

Mouse   480 RELLLQPVKPIVL 492
             |:...| |..||
  Fly   504 -EMRFDP-KAFVL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	142/489 (29%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	131/450 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820