DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a16 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	161/513 - (31%)
Similarity:	268/513 - (52%)	Gaps:	49/513 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 TLVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGTVLN----YYKGLWKFDMECYEKYGKT 71
            ||:||..:|..|..|.......::.:|||..:|....|....    :|..|.:...:.:....|.
  Fly     4 TLLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQETYDAFRGSAKV 68

Mouse    72 WGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFFPVGIMSKSISLAKDEEWKRYRALLSPT 136
            .|.:....|:.|:.|.:.:|.||::: |:.|.:|:.|....:.:...:| :.|||:..|..||||
  Fly    69 AGTYVFLRPMAVVLDLDLVKAVLIRD-FNNFVDRRSFHGDPLTANLFNL-QGEEWRNLRTKLSPT 131

Mouse   137 FTSGNLKEMF----PVIEQYG---DILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNID 194
            ||||.:|.||    .|.:|.|   |.||      ..:|..:.:.|::..|:.|||.|..||....
  Fly   132 FTSGKMKYMFGTVSTVAQQLGGTFDELV------GSQGAVLELHDLMARYTTDVIGSCAFGTECS 190

Mouse   195 SLNNPEDPF-------VENAKKVLRFDYFDPLSLSVALFPFLTPIYEM-LNICMFPKDSIEFFKK 251
            ||..|:..|       ..|:.:.:|:..|.        ..:|:.:.:: |.:.:...|..:||.:
  Fly   191 SLREPQAEFRQVGRRIFRNSNRSIRWRIFK--------MTYLSSLAKLGLPVRILHPDITKFFNR 247

Mouse   252 FVDRMTENRLDSKQKHRVDFIYLMMEAYNKSKDKDSHKALSEIEITAQSIIFIFAGYETTSSILS 316
            .|....|.| :.:...|.||:.|:::.    :.:::.|.|:..::.||:.:|..||:||:||.:|
  Fly   248 IVRETVELR-ERENIRRNDFMDLLLDL----RRQENGKGLTMEQMAAQAFVFFVAGFETSSSNMS 307

Mouse   317 FTVYSLATHPDIQKKLQEEIDEALPNKAPPTYDTVMAMEYLDMVLNETLRLYPITNRLQRVCKKD 381
            :.::.||.:.|:|:||:.||::::......||:.:|.|.|||..:.||||.||..:.|.|:..:|
  Fly   308 YALFELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRLASED 372

Mouse   382 VEI------NGIYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYLPFGNGP 440
            .||      :.:.:.||::|.||...:|:||:.:|||.||:||||:.:......|..:|.||:||
  Fly   373 YEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGP 437

Mouse   441 RNCIGMRFALMNMKLALIKVLQNFSFQ--PCKETQIPLKLSRELLLQPVKPIVLKVVP 496
            |||||:||..|.:|:.||.:|:.|.|.  |...||:.: ..|.|:|.|...:.|:|.|
  Fly   438 RNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKV-TKRNLILLPSDGVRLQVDP 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	150/481 (31%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	150/481 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820