DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a13 and Cyp4p1

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_524828.1	Gene:	Cyp4p1 / 45524	FlyBaseID:	FBgn0015037	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	145/543 - (26%)
Similarity:	251/543 - (46%)	Gaps:	93/543 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 WMLLATSLVLLYLYGT----HSHGIF-KKLGIPGPKPLP-----------FLGTILAYQK---GF 57
            |::||.|.:|.:|:..    |....| |::.:....|:.           |..|:..|.:   |.
  Fly     5 WLILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYGRDHAGV 69

Mouse    58 WECDIQCHKKYGKMWGLYDGRQPVLAITDPDIIKTVL------VKECYSTFTNRRRFGPVGILKK 116
            :....:..|:.|..:..|...:.:..|.|.|..:.||      .|.....|.:       ..|:.
  Fly    70 FNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHPNLITKGLVYNFLH-------PFLRT 127

Mouse   117 AISISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGL----GEGKPT-SMKDIF 176
            .:..|..::|...|.:|:|||       .|.|:|||.::.....::.|    |:.:.| ::.|:.
  Fly   128 GLLTSTGKKWHARRKMLTPTF-------HFNILNQFQEIFKTESQKFLLQFEGQDEVTITLHDVI 185

Mouse   177 GAYSMDVITATSFGVNIDSLNNPQDPFVE---KIKKLLKFDIFDPLFLSVTLFP-FLTPVF-DAL 236
            ..::::.|..|:.||.:|.:....|.:.|   :|::.....:.:||.....||. |....| .||
  Fly   186 PRFTLNSICETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEMFAAKDFASAL 250

Mouse   237 NVSLFPRDVISFFTTSVERMKENRMKEK--------------EKQRVDFLQLMINSQNYKTKESH 287
                   ||:..|::.:...:.:.:|::              .|:|...|..:|    |..|:.
  Fly   251 -------DVVHRFSSEIIAKRRDLLKDELDKSSSTADDDGFVSKKRFAMLDTLI----YAEKDG- 303

Mouse   288 KALSDVEIVAQSVIFIFAGYETTSSALSFALYLLAIHPDVQ----KKLQDEIDAALPNKAPATYD 348
             .:..:.|..:....:|.||:|||..|.|.|..::::||.|    :::|:.||..|.|   ....
  Fly   304 -LIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHIDDDLSN---LDVG 364

Mouse   349 TLLQMEYLDMVVNETLRLY---PIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPE 410
            .|.:::||:..:.||.||:   ||.|| |.|.:|:: .|||.:|||..:.|..|.:|::.|||..
  Fly   365 QLNKLKYLEYFMKETTRLFPSVPIMGR-EAVQETEL-ANGLILPKGAQITIHVFDIHRNAKYWDS 427

Mouse   411 PEEFRPERFSKKNQDSINPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPL 475
            |||||||||..:|....:.|.|:||.:|.|||||.::|:..||..:|.:|:.|.|....:   |.
  Fly   428 PEEFRPERFLPENVQDRHTYAYVPFSAGQRNCIGKKYAMQEMKTLMVVLLKQFKVLKAID---PQ 489

Mouse   476 KL-SKQGL-LQPENPLLLKVVSR 496
            |: ...|: |:.::.:.:|:|.|
  Fly   490 KIVFHTGITLRTQDKIRVKLVRR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	133/504 (26%)
Cyp4p1	NP_524828.1	p450	54..509	CDD:278495	132/489 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910