DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a13 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	133/522 - (25%)
Similarity:	245/522 - (46%)	Gaps:	82/522 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 WMLLATSLVL-LYLYGTHSHGIFKKLGI----PGPKPLPFLGTILAYQK------------GFWE 59
            |::|...|.| |:|......|:.::..:    .||..||.:|.  |:|.            |:|.
  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGN--AHQMGNTPTEILNRFFGWWH 64

Mouse    60 CDIQCHKKYGK----MW-GLYDGRQPVLAITDPDIIKTVLVKECY----STFTNRRRFGPVGILK 115
                   :|||    .| |.|..    :.:|:|..::.:|..:..    ..:.....:..:|:|
  Fly    65 -------EYGKDNFRYWIGYYSN----IMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLL- 117

Mouse   116 KAISISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYS 180
                .|...:|.:.|.:::|.|....|::...::|:.:...:..:::....|.....::.....:
  Fly   118 ----TSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLT 178

Mouse   181 MDVITATSFGVNIDSLNNPQDPFVEKIKKL---LKFDIFDPLFLSVTLFPFLTPVFDALNVSL-- 240
            :|||..|:.||:|:::.|.....|:..|.:   :|...|.|...:..||.| .|.:...:.:|
  Fly   179 LDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTLKT 242

Mouse   241 ---FPRDVISFFTTSVERMKEN-----RMKEKEKQRVDFLQLMINSQNYKTKESHKALSDVEIVA 297
               |..::|:   ..:|..|..     :..|..::::.||..:::|     |...:.|:..|:..
  Fly   243 LQDFTNEIIA---KRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSS-----KVDGRPLTSQELYE 299

Mouse   298 QSVIFIFAGYETTSSALSFALYLLAIHPDVQKKL---QDEIDAALPNKAPATYDTLLQMEYLDMV 359
            :...|:|.|::||:|.:.||:|||:.|||.|:||   |.::..|......||:..:..|::||:.
  Fly   300 EVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLF 364

Mouse   360 VNETLRLYPIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQ 424
            :.|..||||....:.|..:.|..|:|..:||||.:.:....|..:.:.:.:|.:|:||||.::..
  Fly   365 IKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKP 429

Mouse   425 DSINPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGL------L 483
               .|:.|:||.:|||||||.:|||:.:|..:.::::||.|.|..:..:    ||.|.      |
  Fly   430 ---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV----SKDGYISTTLGL 487

Mouse   484 QP 485
            ||
  Fly   488 QP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	126/490 (26%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	119/464 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810