DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a13 and Cyp9c1

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_523850.1	Gene:	Cyp9c1 / 37941	FlyBaseID:	FBgn0015040	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	159/518 - (30%)
Similarity:	283/518 - (54%)	Gaps:	54/518 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 VLLYLYGTHSHGIFKKLGIPGPKPLPFLG----TILAYQKGFWECDIQCH--KKYGKMWGLYDGR 78
            :|||.:..::.|.|.|.|:...||:|.||    ::|..::.:.:..|..|  .|..|::|:::.|
  Fly    15 LLLYKWSVYTFGYFSKRGVAHEKPIPLLGNIPWSVLMGKESYIKHSIDLHLRLKQHKVYGVFNLR 79

Mouse    79 QPVLAITDPDIIKTVLVKECYSTFTNRRR-----FGPVGILKKAISISENEEWKRIRALLSPTFT 138
            .|:..::||::|:.|.:|. :.||||.|:     |....::.|::....:..||::|:.|:||||
  Fly    80 DPLYYLSDPELIRQVGIKN-FDTFTNHRKGITEGFNDTSVISKSLLSLRDRRWKQMRSTLTPTFT 143

Mouse   139 SGRLKEMFPIIN----QFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFGVNIDSLNNP 199
            |.::::||.:|:    :..|.:.|.:..|..|   ..:||.|..|:.|||...:||:.::|..:|
  Fly   144 SLKIRQMFELIHFCNVEAVDFVQRQLDAGTSE---LELKDFFTRYTNDVIATAAFGIQVNSFKDP 205

Mouse   200 QDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPVFDALNVSLFPRDVISFFTTSVERMKENRMKEK 264
            .:.|....:::.:|..:..  |.|.|:..:..:..||.|.:...:.:.:|    :::....||.:
  Fly   206 NNEFFSIGQRISEFTFWGG--LKVMLYILMPKLMKALRVPVMDMNNVDYF----KKLVFGAMKYR 264

Mouse   265 EKQ---RVDFLQLMINSQ-NYKTKESHKA----------LSDVEIVAQSVIFIFAGYETTSSALS 315
            ::|   |.|.:.|::.:| .:|.::...|          .:|.:::||.::|..||:||.::.||
  Fly   265 KEQSIVRPDMIHLLMEAQRQFKAEQEGSAESAAQQDKAEFNDDDLLAQCLLFFSAGFETVATCLS 329

Mouse   316 FALYLLAIHPDVQKKLQDEIDAALP--NKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCK 378
            |..|.|.::|:||:||..||.|...  .:.|..||||:.|:||:.||:|:||.:|.|..::|:|.
  Fly   330 FTSYELMMNPEVQEKLLAEILAVKEQLGEKPLDYDTLMGMKYLNCVVSESLRKWPPAFIVDRMCG 394

Mouse   379 TDVEINGLFIPKGTVVM---------IPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYLP 434
            :|.::..   .:|.||:         |...|||.||..:||||:||||||.::::..|..:.|||
  Fly   395 SDFQLKD---EEGEVVVNLREDDLVHINVGALHHDPDNFPEPEQFRPERFDEEHKHEIRQFTYLP 456

Mouse   435 FGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGL-LQPENPLLLKVVSR 496
            ||.|.|:|||.|.||:.:|..:.:::..:.::|...|...:..|..|. |.|......|:.||
  Fly   457 FGVGQRSCIGNRLALMEVKSLIFQLVLRYHLKPTDRTPADMMSSISGFRLLPRELFWCKLESR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	149/492 (30%)
Cyp9c1	NP_523850.1	p450	37..514	CDD:299894	149/489 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.790