DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a13 and Cyp6a20

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	163/518 - (31%)
Similarity:	265/518 - (51%)	Gaps:	53/518 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 METWMLLATSLVLLYLYGTHSH-GIFKKLGIPGPKP-LPFLGTILAYQKGFWECDIQCHKKYGKM 71
            |...::|...::....:..|.| ..:|:.|||..:| :|: |......|.....|| ..:.|.|:
  Fly     1 MAVMIVLLIGVITFVAWYVHQHFNYWKRRGIPHDEPKIPY-GNTSELMKTVHFADI-FKRTYNKL 63

Mouse    72 WGLYDGR--------QPVLAITDPDIIKTVLVKECYSTFTNR-----RRFGPVGILKKAISISEN 123
            ....||.        :.::.:||.|..||||::| :..|.:|     .|..|:.  ...::| :.
  Fly    64 RNKTDGPFVGFYMYFKRMVVVTDIDFAKTVLIRE-FDKFHDRGVFHNERDDPLS--ANLVNI-DG 124

Mouse   124 EEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQ-GLGEGKPTSMKDIFGAYSMDVITAT 187
            ::||.:|..|:||||||::|.|||.|....|.|:|...: ...:.....:.::...::.|||.:.
  Fly   125 QKWKTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSC 189

Mouse   188 SFGVNIDSLNNPQDPFVEKIKKLL------KFDIFDPLFLSVTLFPFLTPVFDA-LNVSLFPRDV 245
            :||::..||::|:..||:.....:      |         |:.|..|..|...| |.:....::|
  Fly   190 AFGLDCHSLSDPKAKFVQMGTTAITERRHGK---------SMDLLLFGAPELAAKLRMKATVQEV 245

Mouse   246 ISFFTTSVERMKENRMKEKEKQRVDFLQLMINSQ-NYKTKESHKALSDVEIVAQSVIFIFAGYET 309
            ..|:...:....:.|:|...| |.||:.::|..: .:...:....|:..||.||:.||..||:||
  Fly   246 EDFYMNIIRDTVDYRVKNNVK-RHDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIFFLAGFET 309

Mouse   310 TSSALSFALYLLAIHPDVQKKLQDEIDAAL-PNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRL 373
            :|:.:.||||.||.|.|:|.||:.||:..| .:.....||::.:|.||:.|::||:|..|:.|.|
  Fly   310 SSTTMGFALYELACHQDIQDKLRTEINTVLKQHNGKLDYDSMREMTYLEKVIDETMRKRPVVGHL 374

Mouse   374 ERVC-----KTDVEINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYL 433
            .||.     .|:.:.|   |.|||.|::||.|:|.||:::||||:|.||||.:..........:|
  Fly   375 IRVATQHYQHTNPKYN---IEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQRPACTFL 436

Mouse   434 PFGSGPRNCIGMRFALINMKVALVRVLQNFTVQ--PCKETEIPLKL-SKQGLLQPENPLLLKV 493
            |||.|||||||:||..:.:.|.:..::.||..:  |.| |.:||:. :...||..:..:.|||
  Fly   437 PFGDGPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTK-TVVPLEYRTDDFLLSSKGGIHLKV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	153/483 (32%)
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	153/483 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710