DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp3a13 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	162/528 - (30%)
Similarity:	274/528 - (51%)	Gaps:	53/528 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 SMETWMLLATSLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTI--------LAYQKGFWECDIQC 64
            ||....|....|||||.:....:.:|.:.|:...||.|.:|.|        :...|..    |:.
  Fly     4 SMIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKM----IEL 64

Mouse    65 HKKY--GKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFG---PVGILKKAISISENE 124
            |.|:  ..::|:|..|..|..:.||::||.:.:|| :..|.|.....   ...||.|::....:.
  Fly    65 HTKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISLRDG 128

Mouse   125 EWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTS----MKDIFGAYSMDVIT 185
            .||.:|.:|:|.||..:::.|:.:|...::..|.::::.|...:..|    |||.|..::.|||.
  Fly   129 RWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVIA 193

Mouse   186 ATSFGVNIDSLNNPQDPFV---EKIKKLLKFDIFDPLFLSVTLFPFLTPVFDALNVSLFPRDVIS 247
            ..:||::|:|.....:.|.   :.:.::..:.:...:..:  |||.|..|   |.:.:.....|.
  Fly   194 TVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYA--LFPRLMKV---LRIQVLDTKNID 253

Mouse   248 FFTTSVERMKENRMKEKEKQRVDFLQLMINSQNYKTKE-SHKALSDV--------EIVAQSVIFI 303
            :|::.|......| :|.:..|.|.:.|::.::..:..: |.|:..::        :::||.::|.
  Fly   254 YFSSLVTAAMRYR-QEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFF 317

Mouse   304 FAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAA---LPNKAPATYDTLLQMEYLDMVVNETLR 365
            |||:|..||:|.|..:.|.::|.||.:|.:||.:.   |..: |.|||.|.:|:||||||.|.||
  Fly   318 FAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYLDMVVLEALR 381

Mouse   366 LYPIAGRLERVCKTDVEI---NG--LF-IPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQ 424
            .:|.:...:|.|:.|:::   ||  || ..||.|:.||.|:||.||:.:.:||.|.||||:  :.
  Fly   382 KWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFA--DG 444

Mouse   425 DSINPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGL-LQPENP 488
            .::...:|:|||.|||||||.|.||:.:|..:.::|.||.:.|.|.|...|....:|. |:|:|.
  Fly   445 HALESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLKPKNG 509

Mouse   489 LLLKVVSR 496
            ..||..:|
  Fly   510 FWLKFEAR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	149/490 (30%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	149/487 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760