DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a13 and Cyp6t3

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	149/516 - (28%)
Similarity:	247/516 - (47%)	Gaps:	60/516 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 WMLLATSLVLLYLYGTHSHGIFKKLGIP-----GPKPLPFLGTILAYQKGFWECDIQCH----KK 67
            |:||.| :|.|..:..|.:..|:..|||     ...|:..||.:|..:..|.:...|.:    ..
  Fly     5 WLLLLT-IVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPRNG 68

Mouse    68 YGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFG----PVGILKKAISISENEEWKR 128
            ..|:.|.:..:.|.|.:.||::|:.||:|. ::.|.||....    |:|.|  .:.:::...||.
  Fly    69 QAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGAL--TLPLAKYHHWKE 130

Mouse   129 IRALLSPTFTSGRLKEMFPIINQFTDV---LVRNMRQGLGE--------GKPTSMKDIFGAYSMD 182
            .|..:|..|||||::::  :.:|..||   |.:.:.:.||:        |:...:      |:.|
  Fly   131 SRQCMSQLFTSGRMRDV--MYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQL------YTTD 187

Mouse   183 VITATSFGVNIDSLNNPQDPFVEKIKKLLKFD---IFDPLFLSVTLFPFLTPVFDALNVSLFPRD 244
            |.....:.:|:..|...:...:.|.|:|...:   :.|  |:||...|..|.|   |...:|..|
  Fly   188 VTGNLFYSLNVGGLRRGRSELITKTKELFNTNPRKVLD--FMSVFFLPKWTGV---LKPKVFTED 247

Mouse   245 VISFFTTSVERMKENRMKEKEKQRVDFLQLMINSQNYKTKESHKALSDVEIVAQSVIFIFAGYET 309
            ...:....|:...|....:...|...| ||..:|.:|......       :.:|:.|.:.||:||
  Fly   248 YARYMRHLVDDHHEPTKGDLINQLQHF-QLSRSSNHYSQHPDF-------VASQAGIILLAGFET 304

Mouse   310 TSSALSFALYLLAIHPDVQKKLQDEIDAALPNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLE 374
            :|:.:.|.||.||..||:|::|:.|:..|..:.|..:||||:.:.||.||..|.|||||.|..:.
  Fly   305 SSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVN 369

Mouse   375 RVCKTDVEIN-------GLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMY 432
            |.|.:.....       ...:|.|....|....||:|.::||||..|.||||..:....|:|..|
  Fly   370 RECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTY 434

Mouse   433 LPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLS-KQGLLQPENPLLLK 492
            :|||:||..|||.|..::.:|:.:|.:|:.:.|:.|:.|...::.: |..:|:.||.:.|:
  Fly   435 IPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	138/486 (28%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	134/475 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810