DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a13 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	170/516 - (32%)
Similarity:	273/516 - (52%)	Gaps:	45/516 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 MLLATSLVLLYL---YGTH--SHGIFKKLGIPGPKPLPFLGTILAYQKGFWECDI--QCHKKY-- 68
            ||...:||.:.|   |..|  ....:|:.|:|...|||.:|.:....|.:...||  :.:||:
  Fly     1 MLFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKG 65

Mouse    69 -GKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRF-----GPVGILKKAISISENEEWK 127
             |.:.|:|...:....|||.|.||.|::|: :|.|.:|..|     .|   |...:...|.|||:
  Fly    66 QGPIAGMYMFFKRTALITDLDFIKQVMIKD-FSYFQDRGAFTNPRDDP---LTGHLFALEGEEWR 126

Mouse   128 RIRALLSPTFTSGRLKEMFPII----NQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATS 188
            .:|..|:|.||||::|:|..:|    .:..|.:.:.:::...|.....:||:...::.|||.:.:
  Fly   127 AMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCA 191

Mouse   189 FGVNIDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFL---TPVFDALNVSLFPRDVISFFT 250
            ||:..:||.:|...|.:|.:     :||.....|..:..|:   ..:...|.:.:.|.|:..||.
  Fly   192 FGLECNSLQDPSAEFRQKGR-----EIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFM 251

Mouse   251 TSVERMKENRMKEKEKQRVDFLQLMINSQNYKTKESHK--------ALSDVEIVAQSVIFIFAGY 307
            ::|:...:.|:|...| |.||::.||..:....:.:.|        .|:..::.||:.:|..||:
  Fly   252 STVKNTVDYRLKNGIK-RNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGF 315

Mouse   308 ETTSSALSFALYLLAIHPDVQKKLQDEIDAALPN--KAPATYDTLLQMEYLDMVVNETLRLYPIA 370
            ||:||.:|..||.||:.||:|::|::||::.|.|  .....||.|.||.|||.|::||||.:|:.
  Fly   316 ETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLL 380

Mouse   371 GRLERVCKTDVEI--NGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYL 433
            ..|.|....|.:|  :.:.:.||.:.:||...:|.||:.:||||:|.|.||..:...:.:|..||
  Fly   381 PHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYL 445

Mouse   434 PFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQG-LLQPENPLLLKV 493
            |||.|||||||:||..|..|:.||.:|:.|.......|::||..||:. ||...:.:.|||
  Fly   446 PFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	158/481 (33%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	159/483 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840