DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a13 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	144/494 - (29%)
Similarity:	245/494 - (49%)	Gaps:	56/494 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    14 LLATSLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTI--LAYQKGFWECDI----QCHKKYGKMW 72
            ::|..|.|:|::.|.:...:||.|||..|..||:|:.  :..||.....||    :.:|....:.
  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIV 74

Mouse    73 GLYDGRQPVLAITDPDIIKTVLVKECYSTFTNR------RRFGPVGILKKAISISENEEWKRIRA 131
            |::..|.|.|.:|.|:....:.|.:..|...|.      .:..|  ||.....:...|.||..||
  Fly    75 GVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDP--ILANNPFVLTGEAWKERRA 137

Mouse   132 LLSPTFTSGRLKEMFP----IINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFGVN 192
            .::|..::.|:|..:|    :..:|.:.:.|.......:|  .:.||:...|:.:||:....|::
  Fly   138 EVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQG--LNAKDLCLCYTTEVISDCVLGIS 200

Mouse   193 IDSLNNPQDPFVEKIKKLLKFDIFDPLFLSV--TLFPFLTPVFDALNVSLFPRDVISFFTTSVER 255
            ..|..:...|.|...|::.: ..|..:|.:|  .|:|   |:....:||||.:||.:||...:::
  Fly   201 AQSFTDNPTPMVGMTKRVFE-QSFGFIFYTVVANLWP---PITKFYSVSLFAKDVAAFFYDLMQK 261

Mouse   256 -MKENRMKEKEKQRVDFLQLMINSQNYKTKESHKALSDVEIVAQSVIFIFAGYETTSSALSFALY 319
             ::..|.....:||.|||..|:..|      ..|.|:..|:.:.::.|:..|:|||:..|:..|.
  Fly   262 CIQVRRESPAAQQRDDFLNYMLQLQ------EKKGLNAAELTSHTMTFLTDGFETTAQVLTHTLL 320

Mouse   320 LLAIHPDVQKKLQDEIDAALPNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEI- 383
            .||.:|..|.||::||     ..|..|::.:.::.:.:..::||||::.......:|.....|:
  Fly   321 FLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELT 380

Mouse   384 --NGLFIP--KGTVVMIPTFALHKDPKYWPEPEEFRPERF------SKKNQDSINPYMYLPFGSG 438
              ||:.:.  .|.||:||..|||.||:|:.||:.|:||||      :||.:|.   .::..||.|
  Fly   381 NKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQ---GLFFGFGDG 442

Mouse   439 PRNCIGMRFALINMKVALVRVLQNFTV----QPCKETEI 473
            ||.|.||||:|..:|.|||.:::||.:    :..|:.||
  Fly   443 PRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEI 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	135/469 (29%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	132/463 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810