DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp3a13 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	148/544 - (27%)
Similarity:	257/544 - (47%)	Gaps:	71/544 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 LIPNFSMETWMLLATSLVLL---------------YLYGTHSHGIFKKLGIPGPKPLPFLGTILA 52
            :|..||:....|...|||||               :|:.......:::||:|.....||:|.:..
  Fly     1 MIAVFSLIAAALAVGSLVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWN 65

Mouse    53 YQKGFWECDIQCHKKYGKMW-GLYDGRQP--------------VLAITDPDIIKTVLVKECYSTF 102
            ..:|  .|   |   :|..: .||:.::.              .|.:.||.:||.::|:: ::.|
  Fly    66 LLRG--AC---C---FGDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVED-FAQF 121

Mouse   103 TNR-RRFGP----VGILKKAISISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQ 162
            ::| ....|    :|  .:.:..|:.|.|:....:.:|.|.:|:::.|:.::......|..:|.|
  Fly   122 SSRFETTDPTCDTMG--SQNLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQ 184

Mouse   163 GLG--EGKPTSMKDIFGAYSMDVITATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDP----LFL 221
            .|.  :.....:|.:...::.|:|.:.:||:...||.||:..|     :.:..::.||    |..
  Fly   185 KLSGRDSMELEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEF-----RRMCIEVNDPRPKRLLH 244

Mouse   222 SVTLFPFLTPVFDALNVSLFPRDVISFFTTSVERMKENRMKEKEKQRVDFLQLMINSQNYKTKES 286
            ..|:| |...:...:...|:..:...|...|::.:...| .|..:.|.|.:.:.:..:..:..||
  Fly   245 LFTMF-FFPRLSHRVGTHLYSEEYERFMRKSMDYVLSQR-AESGENRHDLIDIFLQLKRTEPAES 307

Mouse   287 HKALSDVEIVAQSVIFIFAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAALPNK--APATYDT 349
            .....|. ..||:...:.||::|:||.::||||.||.:..:|.:|:.|:.|||.:.  ...:.||
  Fly   308 IIHRPDF-FAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDT 371

Mouse   350 LLQMEYLDMVVNETLRLYPIAGRLERVC--KTDVEI---NG---LFIPKGTVVMIPTFALHKDPK 406
            :..:.||..||:|.|||||....|:|.|  :|..::   ||   ..:..||.|.|....:|:|.:
  Fly   372 VTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQ 436

Mouse   407 YWPEPEEFRPERFSKKNQDSINPYMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKET 471
            |||.||.|.|||||.:.:...:|..|||||:|||.|||.....:.:||.|:.:|.:|.|:.|:.|
  Fly   437 YWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERT 501

Mouse   472 EIPLKLS-KQGLLQPENPLLLKVV 494
            ...::.. |..:|...|...|:.|
  Fly   502 LPEMRFDPKAFVLTAHNGTYLRFV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	134/488 (27%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	122/434 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810