DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a13 and Cyp311a1

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	145/514 - (28%)
Similarity:	222/514 - (43%)	Gaps:	77/514 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 METWMLLATSLVLLYLYGTHSHGIFKKLG--IPGPKPLPFLGTILAYQKG----------FWECD 61
            |..|.||..:|.:..|....:   ..:||  :|||...|.||.  |...|          |.|
  Fly     1 MALWPLLLITLTIWILVRKWT---LLRLGSSLPGPWAFPLLGN--AQMVGKLRPEYIFLVFTE-- 58

Mouse    62 IQCHKKYG---------KMW-GLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFGPVGILKK 116
              ...::|         ::| .|:...:...|:.||.:.|.       .||.........|:|
  Fly    59 --LRDRFGATYRLRLGPQLWVFLHSAEETRQALHDPTLRKA-------DTFMQLEPLIGNGLL-- 112

Mouse   117 AISISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSM 181
               ||....|.|.|.||:|.|....|:...|.|....:.||.  |.|...|....:.:...|..:
  Fly   113 ---ISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVG--RLGATRGAFLEVTEPLFACLL 172

Mouse   182 DVITATSFGVNIDSLNNPQDPFVEKI---KKLLKFDIFDPLFLSVTLFPFLTPVFDALNVSLFPR 243
            |.|..||.|..:|:.:....|.::..   .|||...:.:||..|..:|. .|.::..|:..|
  Fly   173 DAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQ-RTQLWRDLDEQL--- 233

Mouse   244 DVISFFTTSVERMKENRMKE---------KEKQRVDFLQLMINSQNYKTKESHKALSDVEIVAQS 299
            .||.   :.:|.:.|.|.||         :....:|.|.|        .|...::||..||..:.
  Fly   234 QVIH---SQMESVIEKRAKELLDMGEPAGRAHNLLDTLLL--------AKFEGQSLSRREIRDEI 287

Mouse   300 VIFIFAGYETTSSALSFALYLLAIHPDVQKKLQDEI-DAALPNKAPATYDTLLQMEYLDMVVNET 363
            ..|:|||.:||::|:||.||.||..|:.|.:|:.|: |.||..  ....|.|..:.||:.::.|.
  Fly   288 NTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALDE--TTDLDALNGLPYLEALIKEV 350

Mouse   364 LRLYPIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSIN 428
            ||||.|.....|......||.|.....|..:.|..:.|..|.:|:|:|..|:|||:..::.....
  Fly   351 LRLYTIVPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAP 415

Mouse   429 P-YMYLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQGLLQPE 486
            | :.|:||..||..|||.|::|:.||:...|:::.|.::...| :.||:|..|.:|:.:
  Fly   416 PAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPE-QAPLRLEAQMVLKAQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	137/482 (28%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	137/482 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910