DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a13 and Cyp4d2

DIOPT Version :9

Sequence 1:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus
Sequence 2:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	150/491 - (30%)
Similarity:	255/491 - (51%)	Gaps:	61/491 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 MLLATSLVLL--YLYGTHSHGIFKKLGIPGPKPLPFLGTILAYQ----KGFWECDIQCHKKYGKM 71
            :|:|.:.:||  :|:....:||     :|||:||||||.:|.|:    :...:...:..:|||::
  Fly     9 LLVAFATLLLWDFLWRRRGNGI-----LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRL 68

Mouse    72 WGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRRFGPVGILKKAIS--------ISENEEWKR 128
            :.::...|..:..|||..|:.||..:.:.|..|         |.|.::        :|...:|..
  Fly    69 YRVWILHQLAVFSTDPRDIEFVLSSQQHITKNN---------LYKLLNCWLGDGLLMSTGRKWHG 124

Mouse   129 IRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGEGKPTSMKDIFGAYSMDVITATSFGVNI 193
            .|.:::|||....|::...|.:|.:.|:|..::.......|.::..:....::|:|..|:.|..|
  Fly   125 RRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKI 189

Mouse   194 DSLNNPQDPFVEKIKKLLKFDI--FDPLFLSVTLFPFLTPVFDALNVSLFPRD----VISFFT-- 250
            ::..||..|:|:.:..:....|  |...:..|.....||...:|..     :|    |:..||
  Fly   190 NAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKR-----QDKAIKVMHDFTEN 249

Mouse   251 -------TSVERMKENRMKEK-----EKQRVDFLQLMINSQNYKTKESHKALSDVEIVAQSVIFI 303
                   |.|...||...:|:     :|:|:..|.:::.|    |.:. ..|||.:|..:...|:
  Fly   250 IIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQS----TIDG-APLSDEDIREEVDTFM 309

Mouse   304 FAGYETTSSALSFALYLLAIHPDVQKKLQDEIDAAL--PNKAPATYDTLLQMEYLDMVVNETLRL 366
            |.|::||:||:||.||.::.||:||::||.||...|  ..|:|.|...|.::::::.|:.|:|||
  Fly   310 FEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRL 374

Mouse   367 YPIAGRLERVCKTDVEINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYM 431
            :|....:.|....||||.|..||.||...:..|.|.:||:|:..|:|||||||. .:...|:||.
  Fly   375 HPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD-ADVPQIHPYA 438

Mouse   432 YLPFGSGPRNCIGMRFALINMKVALVRVLQNFTVQP 467
            |:||.:|||||||.:||::.||..:.::|::|.:.|
  Fly   439 YIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	143/463 (31%)
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	143/463 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810