DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp3a11 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	138/533 - (25%)
Similarity:	251/533 - (47%)	Gaps:	82/533 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 WVLLA------ISLVLLYRYG--TRKHELFKKQGIPGPKPLPFLGT----------VLNYYKGLW 58
            |::|.      :.||..:..|  .||..|.|.|   ||..||.:|.          :||.:.|.|
  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQ---GPSMLPLVGNAHQMGNTPTEILNRFFGWW 63

Mouse    59 KFDMECYKKYGK-TWGLFDGQTPLLAVTDPETIKNVLVKECF----SVFTNRRDFGPVGIMSKAI 118
                   .:||| .:..:.|....:.||:|:.::.:|..:..    .|:.....:..:|:::
  Fly    64 -------HEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLT--- 118

Mouse   119 SISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDV 183
              |...:|.::|.:::|.|....|::...|:.:.....:..|::.|..|.....::.....::||
  Fly   119 --STGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDV 181

Mouse   184 ITSTSFGVNVDSLNNPEDPFVEKAKKL---LRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDS 245
            |..|:.||:::::.|.....|:..|.:   ::...|.|...:..||.| .|.|...:..:  |..
  Fly   182 ICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTL--KTL 243

Mouse   246 IEFFKKFVDRMKESR---------LDSKQKHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSI 301
            .:|..:.:.:..|.|         .|...:.::.||..:::|      ||..:.|:..|:..:..
  Fly   244 QDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSS------KVDGRPLTSQELYEEVS 302

Mouse   302 IFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKA---PPTYDTVMEMEYLDMVLNE 363
            .|:|.|::||:|.:.|.::.|:.|||.|:||.:|..:.:....   ..|:..:..|::||:.:.|
  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367

Mouse   364 TLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSI 428
            ..||||....:.|..:||..::|..:|||:|:.:....|.::.:.:.:|.:||||||.:|..|
  Fly   368 AQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG-- 430

Mouse   429 DPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGL------LQP- 486
             |:.|:||..|||||:|.:|||:.:|..::||::||...|..:..:    |:.|.      |||
  Fly   431 -PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV----SKDGYISTTLGLQPA 490

Mouse   487 EKPIVLKVVPRDA 499
            ||.      .|||
  Fly   491 EKK------SRDA 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	125/491 (25%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	118/461 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810