DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp3a11 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	140/548 - (25%)
Similarity:	261/548 - (47%)	Gaps:	86/548 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 LVSALSLETWVLLAISLVLLYRYGTRKHELFKK-QGIPGPKPLPFLGTVL----------NYYKG 56
            ::|..|..|..||...|:.|..|..|:..|.|. :.||||..:||||..:          |...|
  Fly    22 VISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIG 86

Mouse    57 LWKFDMECYKKYGKTWG-------LFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDF-GPVGI 113
            :.|.           ||       ::.|..|.:.:.:|||::.:|..:.|...::..|: .|  .
  Fly    87 MQKL-----------WGTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHP--W 138

Mouse   114 MSKAISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGA 178
            :.:.:..|.|.:|...|.:|:|.|....|.:...|..:...:|.:.|..:. ..:...:...:..
  Fly   139 LGEGLLTSTDRKWHSRRKILTPAFHFKILDDFIDVFNEQSAVLARKLAVEV-GSEAFNLFPYVTL 202

Mouse   179 YSMDVITSTSFGVNVDSLNNPEDPFVE------------KAKKLLRFDFFDPLLFSVVLFPFLTP 231
            .::|::..|:.|..:.:.:|.|..:|:            :||..|:.||    :||      ||.
  Fly   203 CTLDIVCETAMGRRIYAQSNSESEYVKAVYGIGSIVQSRQAKIWLQSDF----IFS------LTA 257

Mouse   232 VYEMLNICMFPKDSIEFFKKFVDRMKESRL-------------------DSKQKHRVDFLQLMMN 277
            .|::....:   :::..|...|.|.:::.|                   |..:|.|:.||.|:::
  Fly   258 EYKLHQSYI---NTLHGFSNMVIRERKAELAILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLID 319

Mouse   278 SHNNSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEAL-- 340
            :   ||:..   .||:.:|..:...|:|.|::|||:.:|:||..|..||:.|:::.:|:|...
  Fly   320 A---SKEGT---VLSNEDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGD 378

Mouse   341 PNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHD 405
            ..:.|.|...:|:|.||:..:.::|||:|....:.|:..:||.:.|..:|.|:..:|.:||||.:
  Fly   379 DKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNIGGKIVPAGTQAIIMTYALHRN 443

Mouse   406 PQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCK 470
            |:.:.:||:|.|:.|..||.....|:.|:||..|||||:|.:||::..|..::.:::.:..:...
  Fly   444 PRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVD 508

Mouse   471 ETQIPLKLSRQGLLQPEKPIVLKVVPRD 498
            ..: .|.|..:.:|:|:..:.:|:.|||
  Fly   509 RRE-DLTLLGELILRPKDGLRVKITPRD 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	124/505 (25%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	124/505 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810