Protein Alignment Cyp3a11 and Cyp6d4

DIOPT Version :10

• Sequence 1: NP_031844.1
• Gene: Cyp3a11 / 13112
• MGIID: 88609
• Length: 504
• Species: Mus musculus
• Sequence 2: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 185/534 - (34%)
• Similarity: 293/534 - (54%)
• Gaps: 77/534 - (14%)

Mouse    13 VLLAISLV-LLYRYGTRKHELFKKQGIPGPK--PLPF--LGTVLNYYK--GLWKFDMECYKKYGK 70
            :|||::|: |.:.|..|.:|.::::|.|..|  .:||  |.:|....|  ||..:|: ..|...:
  Fly     5 ILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWRQEKSMGLAIYDV-YVKSKER 68

Mouse    71 TWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNR-------RDFGPVGIMSKAISISKDDEWKR 128
            ..|::....|.:.:.|.:..:.||.:: |:.|.:|       ||  |   :|..|...:...|:.
  Fly    69 VLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDRGVYVDEERD--P---LSANIFSLRGQSWRS 127

Mouse   129 YRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQK-AKKG-KPVTMKDVLGAYSMDVITSTSFGV 191
            .|.:|||.|||||||.||...|..||.:|.:|::: .::| |.|.:|.|:..|::|:|.||.||:
  Fly   128 MRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGL 192

Mouse   192 NVDSLNNPEDPF---VEKAKKLLRFD-FFDPLLFSV-----VLF--PFLTPV-YEMLNICMFPKD 244
            :|:|..||::.|   |..|:...||: .|..::|.|     .||  .|..|| ..||.|.   |:
  Fly   193 DVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIV---KE 254

Mouse   245 SIEFFKKFVDRMKESRLDSKQKH---RVDFLQLMMNSHNNSK----DKVSH----------KALS 292
            ::|:               ::||   |.|.|||::...|..|    |:.|.          |.:|
  Fly   255 TVEY---------------REKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTIS 304

Mouse   293 DMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEAL-PNKAPPTYDTVMEMEY 356
            ...||||:.||..||.|||.||.:||::.||.:|::.|:||||:||.| .|....|||::.:||:
  Fly   305 LEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEF 369

Mouse   357 LDMVLNETLRLYPIANRLERVCKKDV---ELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPE 418
            ||:.:.||:|.||....|.|.|.:|.   :.|.| ||||:.|:|..|.:|||.:::.:||.:.||
  Fly   370 LDLCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYFPDPETYDPE 433

Mouse   419 RFSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGL 483
            |||:|:: :.:|..::|||.|||.|:..|...:|.|||:.||:|||:.:....::|..:.|...|
  Fly   434 RFSEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFENSGIAL 497

Mouse   484 LQPEKPIVLKVVPR 497
            : |:..:.:::..|
  Fly   498 I-PKHGVRVRLSKR 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	CYP3A	67..493	CDD:410743	164/467 (35%)
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	164/464 (35%)