DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp3a11 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	185/534 - (34%)
Similarity:	293/534 - (54%)	Gaps:	77/534 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 VLLAISLV-LLYRYGTRKHELFKKQGIPGPK--PLPF--LGTVLNYYK--GLWKFDMECYKKYGK 70
            :|||::|: |.:.|..|.:|.::::|.|..|  .:||  |.:|....|  ||..:|: ..|...:
  Fly     5 ILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWRQEKSMGLAIYDV-YVKSKER 68

Mouse    71 TWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNR-------RDFGPVGIMSKAISISKDDEWKR 128
            ..|::....|.:.:.|.:..:.||.:: |:.|.:|       ||  |   :|..|...:...|:.
  Fly    69 VLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDRGVYVDEERD--P---LSANIFSLRGQSWRS 127

Mouse   129 YRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQK-AKKG-KPVTMKDVLGAYSMDVITSTSFGV 191
            .|.:|||.|||||||.||...|..||.:|.:|::: .::| |.|.:|.|:..|::|:|.||.||:
  Fly   128 MRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGL 192

Mouse   192 NVDSLNNPEDPF---VEKAKKLLRFD-FFDPLLFSV-----VLF--PFLTPV-YEMLNICMFPKD 244
            :|:|..||::.|   |..|:...||: .|..::|.|     .||  .|..|| ..||.|.   |:
  Fly   193 DVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIV---KE 254

Mouse   245 SIEFFKKFVDRMKESRLDSKQKH---RVDFLQLMMNSHNNSK----DKVSH----------KALS 292
            ::|:               ::||   |.|.|||::...|..|    |:.|.          |.:|
  Fly   255 TVEY---------------REKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTIS 304

Mouse   293 DMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEAL-PNKAPPTYDTVMEMEY 356
            ...||||:.||..||.|||.||.:||::.||.:|::.|:||||:||.| .|....|||::.:||:
  Fly   305 LEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEF 369

Mouse   357 LDMVLNETLRLYPIANRLERVCKKDV---ELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPE 418
            ||:.:.||:|.||....|.|.|.:|.   :.|.| ||||:.|:|..|.:|||.:::.:||.:.||
  Fly   370 LDLCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYFPDPETYDPE 433

Mouse   419 RFSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGL 483
            |||:|:: :.:|..::|||.|||.|:..|...:|.|||:.||:|||:.:....::|..:.|...|
  Fly   434 RFSEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFENSGIAL 497

Mouse   484 LQPEKPIVLKVVPR 497
            : |:..:.:::..|
  Fly   498 I-PKHGVRVRLSKR 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	175/502 (35%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	165/469 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820